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Ecotoxicological information

Toxicity to birds

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Description of key information

The key study was a 14-day acute gavage study of the effects of the substance on northern bobwhite (Colinus virginianus), conducted in accordance with an established guideline.   

Key value for chemical safety assessment

Short-term EC50 or LC50 for birds:
1 404.8 mg/kg food

Additional information

In the key study, acute oral toxicity to birds was determined as LD50 = 175.6 mg/kg bw. The NOEL was determined to be less than the lowest level tested (<79.0 mg/kg), based on the examination of body weight, feed consumption, clinical signs of toxicity(e.g., loose excreta, lethargy, laboured breathing, closure of both eyes) and mortality. The key value of LC50 = 1404.8 mg/kg food was derived from the LD50, based on the conversion equation and conversion factor value in ECHA guidance (Equation R.10, and a conversion factor value of 8 for Gallus domesticus, another member of the order Galliformes, fromTable R.10-12; Guidance on Information Requirements and Chemical Safety Assessment Chapter R.10: Characterisation of Dose [Concentration] Response for Environment, May 2008).  Using the same methodology, the NOEL of < 79 mg/kg bw may be represented as a NOEC < 632 mg/kg food.