Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
other: Expert judgement
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well-documented statement meeting basic scientific principles

Data source

Reference
Reference Type:
other: Expert judgement
Title:
Unnamed
Year:
2011
Report date:
2011

Materials and methods

Objective of study:
toxicokinetics

Test material

Constituent 1
Details on test material:
- Name of test material (as cited in study report): Y-15099

Results and discussion

Main ADME resultsopen allclose all
Type:
absorption
Results:
Y-15099 is predicted to be bioavailable.
Type:
distribution
Results:
General tissue accumulation is possible, but the potential is expected to be low.
Type:
metabolism
Results:
Y-15099 has been identified as a potent skin sensitizer. This result confirms that the compound or its metabolites or hydrolysis products are capable of binding to proteins.
Type:
excretion
Results:
For the most metabolites biliary excretion is more likely than renal excretion.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): low bioaccumulation potential based on study results