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Description of key information

Key value for chemical safety assessment

Additional information

Experimental data on toxicokinetics of Y-15099 were not available. The toxicokinetic behaviour was assessed by expert judgement:

Absorption:

Y-15099 is predicted to be bioavailable.

Distribution:

General tissue accumulation is possible, but the potential is expected to be low.

Metabolism:

Y-15099 has been identified as a potent skin sensitizer. This result confirms that the compound or its metabolites or hydrolysis products are capable of binding to proteins.

Excretion:

For the most metabolites biliary excretion is more likely than renal excretion.