Registration Dossier

Administrative data

Endpoint:
relative density
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
Version / remarks:
-
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.3 (Relative Density)
Version / remarks:
-
Deviations:
no
GLP compliance:
no
Type of method:
pycnometer method

Test material

Constituent 1
Chemical structure
Reference substance name:
2,4-Diamino-6-chloropyrimidine-3-oxide
EC Number:
609-076-5
Cas Number:
35139-67-4
Molecular formula:
C4H5ClN4O
IUPAC Name:
2,4-Diamino-6-chloropyrimidine-3-oxide
Test material form:
solid
Remarks:
white/beige solid
Specific details on test material used for the study:
- Analytical purity: > 99%- Lot/batch No.: 0160405- Expiration date of the lot/batch: 21/02/2018

Results and discussion

Densityopen allclose all
Type:
density
Density:
>= 1.584 - <= 1.585 g/cm³
Temp.:
20 °C
Key result
Type:
relative density
Density:
ca. 1.585 g/cm³
Temp.:
20 °C

Any other information on results incl. tables

Calculated Values

First Determination

 

 

 

Error rel.

Error abs.

Temperature

19.8

°C

 

 

0.1

Density of water

0.998203

g/cm3

 

2.00%

0.0002

Volume of Pycnometer

25.5945

cm3

 

 

 

Density of Replacement Liquid

0.7888

 

 

 

 

Density of Test Substance

1.5849

g/cm3

 

0.0496%

0.0008

Second Determination

 

 

 

Error rel.

Error abs.

Temperature

20.2

°C

 

 

0.1

Density of water

0.998203

g/cm3

 

2.00%

0.0002

Volume of Pycnometer

25.5948

cm3

 

 

 

Density of Replacement Liquid

0.7888

g/cm3

 

 

 

Density of Test Substance

1.5843

g/cm3

 

0.0496%

0.0008

rel. = relative; abs. = absolute

 

Presentation of Results

Results of the single determinations with the respective error as well as the mean value and its standard deviation are presented in the following tables:

Results of Single Determinations

Determination

Density in g/cm3

Error ofDeterm. in g/cm3

1

1.5849

0.0008

2

1.5843

0.0008

As the third determination confirmed the result of the first determination, the result of the second determination was not used for the calculation of the mean value.

 

Results – Mean Values

Parameter

Value

Unit

Standard Deviation

Relative Standard Deviation

Volume of Pycnometer

25.59

cm3

0.0002

0.00%

Density of Test Substance

1.5846

g/cm3

0.0004

0.03%

Density of Test Substance

1584.6

kg/m3

0.4

0.03%

Relative Density of

Test Substance

1.5846

 

0.0004

0.03%

Final Result

 

Using the pycnometer method, a density of 1.5846 ± 0.0008 g/cm3at 20 ± 0.2 °Cwas measured. This value is the mean of two independent determinations with the maximum error of a single determination.Standard deviation was 0.0004 g/cm3, showing very good correlation of the two determinations.

 

Applicant's summary and conclusion

Conclusions:
Using the pycnometer method, a density of 1.5846 ± 0.0008 g/cm3 at 20 ± 0.2 °C was measured. This value is the mean of two independent determinations with the maxi-mum error of a single determination.Standard deviation was 0.0004 g/cm3, showing very good correlation of the two determinations.
Executive summary:

The relative density of the test item was determined with a not-GLP compliant study following the standard guideline OECD TG 109. Using the pycnometer method, a density of 1.5846 ± 0.0008 g/cm3 at 20 ± 0.2 °C was measured. This value is the mean of two independent determinations with the maxi-mum error of a single determination. Standard deviation was 0.0004 g/cm3, showing very good correlation of the two determinations.