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EC number: -
CAS number: -
No short-term study is available for
this endpoint. Nevertheless, reliable studies performed according to the
OECD Guideline 203 under GLP are available on the analogue, THPC-urea
monomer (Tetrakis[hydroxymethyl] phosphonium chloride, oligomeric
reaction products with urea) and on one component of the registered
reaction mass, THPS (Tetrakis[hydroxymethyl] phosphonium sulphate). The
96h-EC50 for the THPS was found to be 71 mg/L and the 96h-EC50 for the
THPC-urea monomer was found to be above 100 mg/L.
According to the results of the short
term studies on fish, invertebrates and algae performed with THPS and
with THPC-urea monomer, it appears that the fish is the less sensitive
trophic level for these both analogues.
In addition according to the results of
short term studies performed on invertebrates and algae with the
THPS-urea monomer, it appears that THPS-urea monomer has similar
range of toxicity toward invertebrates and algae than both analogues
THPS and THPC-urea monomer. Therefore,
it could be considered and concluded that the THPS is the most toxic
constituent of the registered reaction mass and that the toxicity of the
reaction mass towards daphnids is managed by the THPS.
For these reasons, it can be expect that THPS-urea monomer will
have the same range of toxicity than both analogues toward fish. Thus
the acute toxicity to fish study is considered of low importance in this
dossier, since the algae model has been shown to be the most sensitive
model for all this chemical family of THP-Urea or THPS. Therefore, it
seemed reasonable not to perform such in vivo fish study since this
endpoint is not useful for the CLP classification and for the risk
assessment and regarding also the limitation use of vertebrae species
In conclusion and according to the
section 1.2 of the annex XI, the short term study on fish does not need
to be conducted.
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