Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

The partition coefficient has been determined using two different methods in a reliable study performed according to standard guidelines (OECD 107 and 117) under GLP.
The shake flash method gives a log Pow < -0.06 at 23°C and pH 5
The HPLC method gives a log Pow <-0.9 at 25°C and pH 5
The two values are considered consistent but the highest value is retained for risk assessment purposes.

Key value for chemical safety assessment

Log Kow (Log Pow):
at the temperature of:
23 °C

Additional information

In order to obtain the test item in its neutral form, the shake flask and HPLC method have been performed with aqueous phase at pH 5.

The key value for chemical safety assessment corresponds to the data obtained with the shake flask method. This method gives a partition coefficient based on measured concentration of test item in water. The concentration in organic phase has been estimated to be equal to the limit of quantification of the analytical method used in the study (titration method).

In the HPLC method, the partition coefficient has been estimated to be lower than the partition coefficient of thiourea. This substance was not eluted by the HPLC column. As the test item is detected before this unretained substance only an estimated value of partition coefficient can be defined with the HPLC method.

Therefore, the result of the shake flask method is considered more precise.