Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
The partition coefficient has been
determined using two different methods in a reliable study performed
according to standard guidelines (OECD 107 and 117) under GLP.
The shake flash method gives a log Pow < -0.06 at 23°C and pH 5
The HPLC method gives a log Pow <-0.9 at 25°C and pH 5
The two values are considered consistent but the highest value is
retained for risk assessment purposes.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -0.06
- at the temperature of:
- 23 °C
Additional information
In order to obtain the test item in its neutral form, the shake flask and HPLC method have been performed with aqueous phase at pH 5.
The key value for chemical safety assessment corresponds to the data obtained with the shake flask method. This method gives a partition coefficient based on measured concentration of test item in water. The concentration in organic phase has been estimated to be equal to the limit of quantification of the analytical method used in the study (titration method).
In the HPLC method, the partition coefficient has been estimated to be lower than the partition coefficient of thiourea. This substance was not eluted by the HPLC column. As the test item is detected before this unretained substance only an estimated value of partition coefficient can be defined with the HPLC method.
Therefore, the result of the shake flask method is considered more precise.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
