Registration Dossier

Diss Factsheets

Administrative data

surface tension
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because based on structure, surface activity is not expected or cannot be predicted
the study does not need to be conducted because surface activity is not a desired property of the material
the study does not need to be conducted because water solubility is below 1 mg/L at 20°C
Justification for type of information:
According to REACH Annex VII/column 2, the study needs only to be conducted if based on structure, surface activity is expected or can be predicted.
The present substance is not intended to be used as a surfactant (i.e. not a desired property), and the chemical structure of the constituents does not contain groups (such as distinct polar and nonpolar parts) indicating that it will have surface-active properties in solution. Moreover, the test does not need to be conducted if the water solubility is below 1 mg/L at 20°C; based on the available data, the present substance is below this threshold, with a measured water solubility of 0.9 mg/L.
Therefore, the study is deemed unnecessary.
Reason / purpose for cross-reference:
data waiving: supporting information

The substance is considered to be slighlty soluble in pure water, with equilibrium reached from 24h. pH of saturated solution: 6.3.

Slightly less soluble in natural medium: 0.69 mg/L at 20°C. (used for ERA)

Water solubility:
0.9 mg/L
at the temperature of:
20 °C

Four reliable and consistent studies are presented:

- (Safepharm 2001), conducted according to EU guideline, flask method, and under GLP, was considered as the key study; the result is relevant for physico-chemical characterisation with standard testing, and is considered as key value for CSA;

- (Safepharm 2003) was designed for ecotoxicity testing, however preparation of saturated stock solution was sufficiently documented, and resulted in a solubility of 0.69 mg/L in reconstituted natural medium; for purpose of ERA, this value is considered more relevant that the above solubility in pure water;

- (Firmenich 2012) performed non-standard testing, but with robust scientific background, and supported the magnitude of order found above, with results ranging between 0.92 and 0.94 mg/L;

- (Fraunhofer 2011) was conducted on a similar substance, i.e. single isomer of the present multiconstituent, so the read-across was considered justified; it confirmed a solubility just below 1 mg/L.

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion