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EC number: 224-506-8 | CAS number: 4390-04-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline N°401, not GLP. Substance identification: commercial name without any details on the substance but MSDS provided by the manufacturer
- Justification for type of information:
- The justification for read across is provided as an attachment in IUCLID Section 13.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline N°401, not GLP. Substance identification: commercial name without any details on the substance but MSDS provided by the manufacturer
- Justification for type of information:
- The justification for read across is provided as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Preliminary study:
- No preliminary study
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No mortality was observed at tested dose, see table 7.2.1/2.
- Clinical signs:
- other: Pilo-erection was observed at the tested dose for all exposed animals which was reversible at the third day of observation.
- Gross pathology:
- No effect was observed at necropsy.
- Other findings:
- Terminal autopsy findings were normal
- Interpretation of results:
- other: Practically non toxic
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Under the test conditions, PETREPAR 147 is not classified according to the criteria of Annex VI to the Directive 67/548/EEC and CLP Regulation 1272/2008.
- Executive summary:
This data is being read across from the source study that tested Hydrocarbons, C14-C17, n-alkanes, ≤2% aromatics based on analogue read across.
PETRAPAR 147 (P-147) was tested for acute oral toxicity in HC/CFY rats in a limit dose assay. The assay was conducted on a group of 10 rats (5 males, 5 females) with a dose of 5000 mg/kg b.w. administered by gavage, as supplied, in a single oral dose (maximum dose volume of 6.4 mL/kg b.w). Examinations for mortality, clinical signs and body weight gain were performed during the 14-day observation period. All surviving animals were necropsied at the end of the observation period.
No deaths occurred. Pilo-erection was observed in all animals shortly after dosing but not at 72-hour observation period. Body weight gain was not affected by treatment. At necropsy, macroscopic examination of main organs showed no abnormalities.
As the acute oral LD50 was found greater than 5000 mg/kg b.w. under the conditions of the test, PETREPAR 147 is not classified according to the criteria of Annex VI to the Directive 67/548/EEC and CLP Regulation 1272/2008.
Table 7.2.1/2: Number of animals dead
Dose (g/kg) |
Mortality ratio (No of death/No dosed) |
||
Male |
Female |
Combined |
|
5.0 |
0/5 |
0/5 |
0/10 |
Sex |
Bodyweight (g) per day |
||
1 |
8 |
15 |
|
Male |
133 132 133 125 130 |
212 210 211 186 207 |
278 274 274 258 280 |
Female |
121 114 112 123 126 |
164 174 166 170 184 |
198 204 204 198 216 |
Signs |
No of rats in group of 5 showing signs |
|
Male |
Female |
|
Pilo-erection |
5 |
5 |
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Guideline study
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Hydrocarbons, C14-C17, n-alkanes, <2% aromatics
- EC Number:
- 917-828-1
- Molecular formula:
- none available - not a single isomer - see remarks
- IUPAC Name:
- Hydrocarbons, C14-C17, n-alkanes, <2% aromatics
- Details on test material:
- - Name of test material (as cited in study report): Petrepar 147 (P-147)
- Substance type: petroleum product, UVCB
- Physical state: colourless liquid
- Analytical purity: 100 % commercial product
- Composition of test material, percentage of components: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: HC/CFY
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hacking and Churchill Limited, Huntington Cambridgeshire, England
- Age at study initiation: 4 to 6 weeks
- Weight at study initiation: 112 to 133g
- Fasting period before study: overnight prior to and approximately 4 hours after dosing
- Housing: by sex, randomly allocated to cages with wire mesh floors
- Diet (e.g. ad libitum): yes: standard laboratory rodent diet
- Water (e.g. ad libitum): yes
- Acclimation period: 8 days prior start of study
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 to 23 °C
- Humidity (%): 56%
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12 h dark/12 h artificial lightening
IN-LIFE DATES: From 18th of May from 1st of June 1984
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- No data
- Doses:
- 5000 mg/kg b.w.
- No. of animals per sex per dose:
- 10 rats (5 males + 5 females)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations at least twice a day; weighing: on days 1, 8 and 15
- Necropsy of survivors performed: yes
- Other examinations performed: Macroscopic post mortem examination was performed. Abdominal and thoracic cavities were opened. Macroscopic appearence of abnormal organs when present was recorded. - Statistics:
- no data
Results and discussion
- Preliminary study:
- No preliminary study
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No mortality was observed at tested dose, see table 7.2.1/2.
- Clinical signs:
- other: Pilo-erection was observed at the tested dose for all exposed animals which was reversible at the third day of observation.
- Gross pathology:
- No effect was observed at necropsy.
- Other findings:
- Terminal autopsy findings were normal
Any other information on results incl. tables
Table 7.2.1/2: Number of animals dead
Dose (g/kg) |
Mortality ratio (No of death/No dosed) |
||
Male |
Female |
Combined |
|
5.0 |
0/5 |
0/5 |
0/10 |
Sex |
Bodyweight (g) per day |
||
1 |
8 |
15 |
|
Male |
133 132 133 125 130 |
212 210 211 186 207 |
278 274 274 258 280 |
Female |
121 114 112 123 126 |
164 174 166 170 184 |
198 204 204 198 216 |
Signs |
No of rats in group of 5 showing signs |
|
Male |
Female |
|
Pilo-erection |
5 |
5 |
Applicant's summary and conclusion
- Interpretation of results:
- other: Practically non toxic
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Under the test conditions, PETREPAR 147 is not classified according to the criteria of Annex VI to the Directive 67/548/EEC and CLP Regulation 1272/2008.
- Executive summary:
PETRAPAR 147 (P-147) was tested for acute oral toxicity in HC/CFY rats in a limit dose assay. The assay was conducted on a group of 10 rats (5 males, 5 females) with a dose of 5000 mg/kg b.w. administered by gavage, as supplied, in a single oral dose (maximum dose volume of 6.4 mL/kg b.w). Examinations for mortality, clinical signs and body weight gain were performed during the 14-day observation period. All surviving animals were necropsied at the end of the observation period.
No deaths occurred. Pilo-erection was observed in all animals shortly after dosing but not at 72-hour observation period. Body weight gain was not affected by treatment. At necropsy, macroscopic examination of main organs showed no abnormalities.
As the acute oral LD50 was found greater than 5000 mg/kg b.w. under the conditions of the test, PETREPAR 147 is not classified according to the criteria of Annex VI to the Directive 67/548/EEC and CLP Regulation 1272/2008.
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