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Long-term toxicity to fish

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The aquatic toxicity toward fish under chronic conditions was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.

The hydrocarbons, C13-C16, isoalkanes, cyclics, <2% aromatics, estimated freshwater fish 28-day NOELR (No Observed Effect Loading Rate) value is >1000 mg/L, based on growth.

 

The 28-day NOELR for Hydrocarbons, C13-C18, n-alkanes, isoalkanes, cyclics, <2% aromatics in Oncorhynchus mykiss is >1000.0 mg/L. Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.

The 28-day NOELR for Hydrocarbons, C14-C17, n-alkanes, <2% aromatics in Oncorhynchus mykiss is >1000.0 mg/L. Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.

The 28-day NOELR for Hydrocarbons, C14-C18, n-alkanes, isoalkanes, cyclics, <2% aromatics in Oncorhynchus mykiss is >1000.0 mg/L. Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.

The 28-day NOELR for Hydrocarbons, C14-C20 (even numbered), n-alkanes, isoalkanes, <2% aromatics in Oncorhynchus mykiss is >1000.0 mg/L. Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.

The 28-day NOELR for Hydrocarbons, C14-C20, n-alkanes, <2% aromatics inOncorhynchus mykissis >1000.0 mg/L. Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.

The 28-day NOELR for Hydrocarbons, C16-C20, n-alkanes, isoalkanes, cyclics, <2% aromatics in Oncorhynchus mykiss is >1000.0 mg/L. Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.

The 28-day NOELR for Icosane in Oncorhynchus mykiss is >1000.0 mg/L. Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.

The 28-day NOELR for Isohexadecane in Oncorhynchus mykiss is >1000.0 mg/L. Results of computer modelling to estimate chronicity in a 28-day freshwater fish study, based on growth, show that this substance will not produce toxicity at or below its maximum attainable water solubility.

Very long term exposure (31 weeks) to 1% n-alkanes in diet reduces fish appetite, fish growth, lipid digestibility and canthaxanthin fixation in rainbow trout. The effects are reversible.

Very long term exposure (45 weeks) to 1% pristane in diet reduces fish appetite, fish growth, lipid digestibility and canthaxanthin fixation in rainbow trout. The effects are reversible.

Very long term exposure (41 weeks) to 1% dodecylcyclohexane in diet reduces fish appetite, fish growth, lipid digestibility and canthaxanthin fixation in rainbow trout. The effects are reversible.

Key value for chemical safety assessment

Additional information

The aquatic toxicity toward fish under chronic conditions was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.