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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Dissociation constant

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Administrative data

Link to relevant study record(s)

Description of key information

The pKa of primary fatty amines are nearly independent from the carbon-chain-length within the range of C8 (Octyl) and C22 (docosyl). Therefore, a value of pKa = 10.6 can be taken as the default value representing unbranched primary fatty amines consisting of carbon chainlengths between C8 - C22.

Key value for chemical safety assessment

pKa at 20°C:
10.6

Additional information

The pKa of primary fatty amines are nearly independent from the carbon-chain-length within the range of C8 (Octyl) and C22 (docosyl). Therefore, a value of pKa = 10.6 can be taken as the default value representing unbranched primary fatty amines consisting of carbon chainlengths between C8 - C22.

pKa pKb Temp [°C] Solvent Method Reference
Octylamine (CAS 111-86-4)
10,65 3,35 25 water condutometric 1
11,20 2,80 18,5 water condutometric 2
10,57 3,43 25 water potentiometric 3
Decylamine (CAS 2016-57-1)
10,64 3,36 25 water condutometric 1
10,60 3,40 25 water not stated 4
9,92 4,08 25 water not stated 5
9,30 4,70 25 water not stated 6
Dodecylamine (CAS 124-22-1)
10,64 3,36 25 water condutometric 1
10,80 3,20 25 not stated not stated 7
10,63 3,37 25 water potentiometric 8
9,00 5,00 not stated not stated not stated 9
Tetradecylamine (CAS 2016-42-4)
10,62 3,38 25 water condutometric 1
Hexadecylamine (CAS 143-27-1)
10,61 3,39 25 water condutometric 1
9,13 4,87 25 water condutometric 10
Octadecylamine (CAS 124-30-1)
10,60 3,40 25 water condutometric 1
Docosanylamine (CAS 14130-06-4)
10,60 3,40 25 water condutometric 1

[1] C. W. Hoerr, M. R. McCorkle, A.W. Ralston, J. Am. Chem. Soc 1943, 65, 328.

[2] G. Vexlearschi, C. R. Hebd. Seances Acad. Sci. 1949, 228, 1656.

[3] G. Vexlearschi, Bull. Soc. Chim. Fr. 1956, 23, 589.

[4] M. Canle L., I. Demirtas, A. Freire, H. Maskill, M. Mishima, Eur. J. Org. Chem. 2004, 2004, 5031.

[5] H. Arnold et al., Tetrahedron Lett. 1969, 10, 137.

[6] W.W. Libus,W. Moska, Bull.Acad.Pol.Sci.,Ser.Sci.Chim. 1972, 20, 897.

[7] K. Gustavii, Acta Pharm. Suecica 1967, 4, 233.

[8] J. Steigman, D. Sussman, J. Am. Chem. Soc. 1967, 89, 6400.

[9] J. Zheng, S. E. Powers, Environ. Sci. Technol. 2003, 37, 3090.

[10] V. E. Belskii, K. A. Derstuganova, R. F. Bakeeva, L. A. Kudryavtseva, B. E. Ivanov, Russ. Chem. Bull., Int. Ed. 1982, 31, 2112.