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EC number: 627-034-4 | CAS number: 1213789-63-9
Dissociation constant
Administrative data
Link to relevant study record(s)
Description of key information
The pKa of primary fatty amines are nearly independent from the carbon-chain-length within the range of C8 (Octyl) and C22 (docosyl). Therefore, a value of pKa = 10.6 can be taken as the default value representing unbranched primary fatty amines consisting of carbon chainlengths between C8 - C22.
Key value for chemical safety assessment
- pKa at 20°C:
- 10.6
Additional information
The pKa of primary fatty amines are nearly independent from the carbon-chain-length within the range of C8 (Octyl) and C22 (docosyl). Therefore, a value of pKa = 10.6 can be taken as the default value representing unbranched primary fatty amines consisting of carbon chainlengths between C8 - C22.
| pKa | pKb | Temp [°C] | Solvent | Method | Reference |
| Octylamine (CAS 111-86-4) | |||||
| 10,65 | 3,35 | 25 | water | condutometric | 1 |
| 11,20 | 2,80 | 18,5 | water | condutometric | 2 |
| 10,57 | 3,43 | 25 | water | potentiometric | 3 |
| Decylamine (CAS 2016-57-1) | |||||
| 10,64 | 3,36 | 25 | water | condutometric | 1 |
| 10,60 | 3,40 | 25 | water | not stated | 4 |
| 9,92 | 4,08 | 25 | water | not stated | 5 |
| 9,30 | 4,70 | 25 | water | not stated | 6 |
| Dodecylamine (CAS 124-22-1) | |||||
| 10,64 | 3,36 | 25 | water | condutometric | 1 |
| 10,80 | 3,20 | 25 | not stated | not stated | 7 |
| 10,63 | 3,37 | 25 | water | potentiometric | 8 |
| 9,00 | 5,00 | not stated | not stated | not stated | 9 |
| Tetradecylamine (CAS 2016-42-4) | |||||
| 10,62 | 3,38 | 25 | water | condutometric | 1 |
| Hexadecylamine (CAS 143-27-1) | |||||
| 10,61 | 3,39 | 25 | water | condutometric | 1 |
| 9,13 | 4,87 | 25 | water | condutometric | 10 |
| Octadecylamine (CAS 124-30-1) | |||||
| 10,60 | 3,40 | 25 | water | condutometric | 1 |
| Docosanylamine (CAS 14130-06-4) | |||||
| 10,60 | 3,40 | 25 | water | condutometric | 1 |
[1] C. W. Hoerr, M. R. McCorkle, A.W. Ralston, J. Am. Chem. Soc 1943, 65, 328.
[2] G. Vexlearschi, C. R. Hebd. Seances Acad. Sci. 1949, 228, 1656.
[3] G. Vexlearschi, Bull. Soc. Chim. Fr. 1956, 23, 589.
[4] M. Canle L., I. Demirtas, A. Freire, H. Maskill, M. Mishima, Eur. J. Org. Chem. 2004, 2004, 5031.
[5] H. Arnold et al., Tetrahedron Lett. 1969, 10, 137.
[6] W.W. Libus,W. Moska, Bull.Acad.Pol.Sci.,Ser.Sci.Chim. 1972, 20, 897.
[7] K. Gustavii, Acta Pharm. Suecica 1967, 4, 233.
[8] J. Steigman, D. Sussman, J. Am. Chem. Soc. 1967, 89, 6400.
[9] J. Zheng, S. E. Powers, Environ. Sci. Technol. 2003, 37, 3090.
[10] V. E. Belskii, K. A. Derstuganova, R. F. Bakeeva, L. A. Kudryavtseva, B. E. Ivanov, Russ. Chem. Bull., Int. Ed. 1982, 31, 2112.
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