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EC number: 627-034-4 | CAS number: 1213789-63-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study according to GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- (Z)-octadec-9-enylamine
- EC Number:
- 204-015-5
- EC Name:
- (Z)-octadec-9-enylamine
- Cas Number:
- 112-90-3
- Molecular formula:
- CH3(CH2)7CH=CH(CH2)7CH2NH2
- IUPAC Name:
- octadec-9-en-1-amine
- Reference substance name:
- Oleyl Alkylamines
- IUPAC Name:
- Oleyl Alkylamines
- Details on test material:
- - Name of test material (as cited in study report): Noram O
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: Sprague-Dawley, ICO: OFA-SD (IOPS Caw)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Iffa Crédeo, 69210 L´Arbresle, France
- Age at study initiation: approx. 6 weeks
- Weight at study initiation: 175 ± 9 g (males); 153 ± 9 g (females)
- Fasting period before study: The day before treatment, the animals were fasted for a period of approx. 18 hours
- Housing: 5 animals of the same sex during the study; they were housed in polycarbonate cages (48x27x20 cm) with stainless steel lid.
- Diet (e.g. ad libitum): ad libitum (except fasting period)
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3
- Humidity (%): 50 ± 20
- Air changes (per hr): The air was non-recycled and filtered.
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Amount of vehicle (if gavage): The test substance in solution in corn oil was administered at a volume of 10 mL/kg (at the dose levels of 200, 500 and 1000 mg/kg). During the limit test (2000 mg/kg; first experiment), the test substance was administered in its original form (volume: 2.5 mL/kg).
- Lot/batch no. (if required): A 24899 91552
- The test substance was heated at approx. 30 °C and then dissolved in corn oil. - Doses:
- First experiment (limit test): 2000 mg/kg
Second experiment: 200, 500, 1000 mg/kg - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days or 28 days (at the dose level of 1000 mg/kg) after treatment
- Frequency of observations and weighing: The animals were observed at least once day for 14 days. The animals were individually weighed just before treatment and then on days 5, 8 and 15.
- Necropsy of survivors performed: yes; on day 15 after treatment
- Other examinations performed: clinical signs, body weight, macroscopic examination of the main organs (digestive tract, heart, kidneys, liver, lungs, pancreas, spleen) - Statistics:
- The LD50 was calculated according to a Probit Analysis, Finney´s method.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 689 mg/kg bw
- 95% CL:
- 472 - 99 999
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 200 mg/kg bw
- 95% CL:
- 1 027 - 9 110
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 000 mg/kg bw
- Mortality:
- For males:
At 200 mg/kg: 20%
At 500 mg/kg: 0%
At 1000 mg/kg: 40%
At 2000 mg/kg: 80%
For females:
At 200 mg/kg: 0%
At 500 mg/kg: 0%
At 1000 mg/kg: 0%
At 2000 mg/kg: 60% - Clinical signs:
- other: At 200 mg/kg: hypokinesia or/and sedation, piloerection and dyspnoea during 4 hours in all animals; between days 8 and 10, abdominal swelling with associated clinical signs in one male animal At 500 mg/kg: hypokinesia or sedation, piloerection and dyspnoe
- Gross pathology:
- Macroscopic examination of the main organs of the animals (found dead during the study or sacrificed at the end of the study) revealed no abnormalities. Due to the absence of macroscopic lesions, no samples were taken for histological examinations.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results of this study, the test material is considered to be harmful if swallowed
- Executive summary:
In an OECD TG 401 study, the test substance "Noram O" (oleylamine), an opaque, non-homogenous liquid (purity 97.9%), was orally applied to Sprague Dawley rats at a doses of 2000, 1000, 500 and 200 mg/kg bw. In a pre-test (limit test) with 2000 mg/kg bw, no vehicle was used. The substance was heated to approximately 30°C and mixed with corn oil for the lower dose groups in the main test. Mortalities were 70, 20, 0, and 10% in the respective dose groups. Males (LD50 approximately 1200 mg/kg bw) were more sensitive compared to females (LD50 approximately 2000 mg/kg bw); the LD50 for both sexes was established at 1689 mg/kg (probit analysis). Clinical signs included: hypokinesia and/or sedation, piloerection and dyspnea, abdominal swelling. Decreases in body weight gain were noted between day 1 to 5 at 200 and 500 mg/kg bw, persisting in one male and one female at 200 mg/kg bw; and at 1000 mg/kg and returning to normal by day 8. Body weight gain was also decreased at 2000 mg/kg bw from day 1 to 8, returning to normal by day 15. No abnormalities were noted at necropsy
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