4H-1,2,4-Triazole, 4-[[bis(4-fluorophenyl)methylsilyl]methyl]-

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1988

Report date:

1988

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

no

Remarks:

The study was conducted according to the test guidelines in effect at the time of study conduct.

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method B.3 (Acute Toxicity (Dermal))

Deviations:

no

Remarks:

The study was conducted according to the test guidelines in effect at the time of study conduct.

GLP compliance:

yes

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

bis(4-fluorophenyl)methyl(4H-1,2,4-triazol-4yl-methyl)silane

EC Number:

600-198-4

Cas Number:

101377-47-3

Molecular formula:

C16H15N3F2Si

IUPAC Name:

bis(4-fluorophenyl)methyl(4H-1,2,4-triazol-4yl-methyl)silane

Details on test material:

- Purity: R7623 Technical, solid

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Age at study initiation:
- Weight at study initiation:
- Fasting period before study:
- Housing:
- Diet (e.g. ad libitum):
- Water (e.g. ad libitum):
- Acclimation period:


ENVIRONMENTAL CONDITIONS
- Temperature (°C):
- Humidity (%):
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light):

Administration / exposure

Type of coverage:

occlusive

Vehicle:

other: 1% aqueous methyl cellulose

Details on dermal exposure:

TEST SITE
- Area of exposure:
- % coverage:
- Type of wrap if used:

REMOVAL OF TEST SUBSTANCE
- Washing (if done):
- Time after start of exposure:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit):
- Concentration (if solution):
- Constant volume or concentration used: yes/no
- For solids, paste formed: yes/no


VEHICLE
- Amount(s) applied (volume or weight with unit):
- Concentration (if solution):

Duration of exposure:

24 hours

Doses:

dose volume was 10 mL/kg bodyweight and the dose level was 2000 mg/kg bodyweight

No. of animals per sex per dose:

5/sex/dose

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: <14 days>
- Frequency of observations:
- Frequency of weighing:
- Necropsy of survivors performed: yes/no
- Other examinations performed:

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

2 000 mg/kg bw

Other findings:

- Organ weights:
- Histopathology:
- Potential target organs:
- Other observations:

Any other information on results incl. tables

Clinical observations:

No mortality occurred and no signs of systemic toxicity were observed during the 14 day observation period. The treated skin surface of one animal (day 4) and another animal (day 7) showed small wounds and small scabs. All animals showed bodyweight gain during the study period.

Macroscopic findings:

Macroscopic examination at necropsy of all animals at the end of the study revealed no test substance related gross abnormalities.

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: other: EEC Directive 83/467/EEC, Annex VI if the EEC Directive 67/548/EEC

Conclusions:

LD50 = 2000 mg/kg bodyweight
Based on the results of this study it is concluded that the test substance has no toxic effect when administered as a single dermal dose to the rat at a dose level of 2000 mg/kg bodyweight. According to the general classification and labelling requirements for dangerous substance (EEC Directive 83/467/EEC, Annex VI if the EEC Directive 67/548/EEC) the test substance should be classified as nontoxic.

Executive summary:

One group of Wistar rats, comprising 5 males and 5 females, received a single dermal dose of R7623 Technical at 2000 mg/kg bodyweight for 24 hours. No mortality occurred during the 14 day observation period. The treated skin surface of the animals showed no major irritant effect. Macroscopic examination at necropsy of all animals at the end of the study revealed no treatment related gross abnormalities. Since no mortality occurred, the dermal LD₅₀value for males and females is given as exceeding 2000 mg/kg bodyweight.