Registration Dossier
Registration Dossier
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EC number: 600-198-4 | CAS number: 101377-47-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test substance, suspended in corn oil, was administered by gavage to male rats as a single oral dose at dose levels of 450, 670, 1000, 1500, and 2250 mg/kg. After dosing, the rats were checked periodically for toxic signs. Surviving rats were weighed and observed for 14 days after dosing.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- bis(4-fluorophenyl)methyl(4H-1,2,4-triazol-4yl-methyl)silane
- EC Number:
- 600-198-4
- Cas Number:
- 101377-47-3
- Molecular formula:
- C16H15N3F2Si
- IUPAC Name:
- bis(4-fluorophenyl)methyl(4H-1,2,4-triazol-4yl-methyl)silane
- Details on test material:
- - Purity: approximately 95%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 450, 670, 1000, 1500, 2250 mg/kg
- No. of animals per sex per dose:
- one
- Control animals:
- no
Results and discussion
Effect levels
- Dose descriptor:
- other: ALD
- Effect level:
- 1 500 mg/kg bw
Any other information on results incl. tables
Rats dosed at 1500 and 2250 mg/kg died.
All rats that died exhibited stained perinea and decreased muscle tone. The rat receiving 2250 mg/kg had a discharge from the eyes and mouth one day after dosing. The rat receiving 1000 mg/kg experienced some hair loss on its abdomen and perineal area.
All rats that died exhibited severe weight loss. All surviving rats exhibited moderate weight loss 1-2 days after dosing followed by normal weight gain.
Applicant's summary and conclusion
- Interpretation of results:
- sligthly toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- ALD = 1500 mg/kg
- Executive summary:
The test substance, suspended in corn oil, was administered by gavage to male rats as a single oral dose at dose levels of 450, 670, 1000, 1500, and 2250 mg/kg. After dosing, the rats were checked periodically for toxic signs. Surviving rats were weighed and observed for 14 days after dosing. Rats dosed at 1500 and 2250 mg/kg died. All rats that died exhibited stained perinea and decreased muscle tone. The rat receiving 2250 mg/kg had a discharge from the eyes and mouth one day after dosing. The rat receiving 1000 mg/kg experienced some hair loss on its abdomen and perineal area. All rats that died exhibited severe weight loss. All surviving rats exhibited moderate weight loss 1-2 days after dosing followed by normal weight gain. The ALD for the test substance in rats is 1500 mg/kg.
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