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Diss Factsheets
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EC number: 203-398-6 | CAS number: 106-44-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: in vitro investigation
Data source
Reference
- Reference Type:
- publication
- Title:
- Permeability of human epidermis to the phenolic compounds
- Author:
- Roberts MS, Anderson RA, Swarbrick J
- Year:
- 1 977
- Bibliographic source:
- J. Pharm. Pharmac. 29, 677-683
Materials and methods
- Principles of method if other than guideline:
- The permeability of p-cresol was measured across epidermal membranes from human abdominal skin in vitro.
- GLP compliance:
- no
Test material
- Reference substance name:
- p-cresol
- EC Number:
- 203-398-6
- EC Name:
- p-cresol
- Cas Number:
- 106-44-5
- Molecular formula:
- C7H8O
- IUPAC Name:
- p-cresol
- Details on test material:
- IUCLID4 Test substance: other TS: p-cresol, purity: reagent grade
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- human
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- see section: any other information on material and method"
Administration / exposure
- Type of coverage:
- other: in vitro
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 250 minutes
- Doses:
- see section" additional information on materials and methods"
- No. of animals per group:
- in vitro study
- Details on study design:
- see section "any other information on materials and methods"
- Details on in vitro test system (if applicable):
- see section "any other information on materials and methods"
Results and discussion
- Signs and symptoms of toxicity:
- not specified
- Remarks:
- in vitro examination
- Dermal irritation:
- not specified
- Remarks:
- in vitro examination
- Absorption in different matrices:
- see section "executive summary"
- Total recovery:
- see section "executive summary"
Percutaneous absorption
- Dose:
- see section "executive summary"
- Remarks on result:
- other: see section "executive summary"
- Remarks:
- in vitro test: see section "executive summary"
- Conversion factor human vs. animal skin:
- no data
Any other information on results incl. tables
see section "executive summary"
Applicant's summary and conclusion
- Executive summary:
The permeability efficient of p-cresol (in vitro human abdominal skin) was 2.92 x 10[exp-4] cm/min and the lag time for a 0.4 %w/v solution was 16 min. The threshold concentration for damage i.e. the aquous concentration at which the permeability coefficient began to increase was 8.85 %w/v.
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