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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
dermal absorption in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: in vitro investigation

Data source

Reference
Reference Type:
publication
Title:
Permeability of human epidermis to the phenolic compounds
Author:
Roberts MS, Anderson RA, Swarbrick J
Year:
1977
Bibliographic source:
J. Pharm. Pharmac. 29, 677-683

Materials and methods

Principles of method if other than guideline:
The permeability of p-cresol was measured across epidermal membranes from human abdominal skin in vitro.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
p-cresol
EC Number:
203-398-6
EC Name:
p-cresol
Cas Number:
106-44-5
Molecular formula:
C7H8O
IUPAC Name:
p-cresol
Details on test material:
IUCLID4 Test substance: other TS: p-cresol, purity: reagent grade
Radiolabelling:
not specified

Test animals

Species:
human
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
see section: any other information on material and method"

Administration / exposure

Type of coverage:
other: in vitro
Vehicle:
unchanged (no vehicle)
Duration of exposure:
250 minutes
Doses:
see section" additional information on materials and methods"
No. of animals per group:
in vitro study
Details on study design:
see section "any other information on materials and methods"
Details on in vitro test system (if applicable):
see section "any other information on materials and methods"

Results and discussion

Signs and symptoms of toxicity:
not specified
Remarks:
in vitro examination
Dermal irritation:
not specified
Remarks:
in vitro examination
Absorption in different matrices:
see section "executive summary"
Total recovery:
see section "executive summary"
Percutaneous absorption
Dose:
see section "executive summary"
Remarks on result:
other: see section "executive summary"
Remarks:
in vitro test: see section "executive summary"
Conversion factor human vs. animal skin:
no data

Any other information on results incl. tables

see section "executive summary"

Applicant's summary and conclusion

Executive summary:

The permeability efficient of p-cresol (in vitro human abdominal skin) was 2.92 x 10[exp-4] cm/min and the lag time for a 0.4 %w/v solution was 16 min. The threshold concentration for damage i.e. the aquous concentration at which the permeability coefficient began to increase was 8.85 %w/v.