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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
12 June 2012 to 15 November 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted to GLP in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Water solubility:
<= 0.001 g/L
Temp.:
20 °C
pH:
2.6
Details on results:
PRELIMINARY TEST
The preliminary estimate of water solubility was ≤7.5 x 10⁻⁵ g/L with respect to tin and ≤4.0 x 10⁻⁴ corrected for test material at 20 °C.

DEFINITIVE TEST
The counts per second relating to the sample solutions are shown in Table 1.
The concentration (g/L) of test material in the sample solutions is shown in Table 2.

Table 1: Sample Solutions Counts Per Second

Solution

Counts Per Second

Tin

Internal standard

Sample 1A

86265.31

647916.71

Sample 1B

69783.71

695797.65

Sample 2A

108410.45

682457.13

Sample 2B

116770.04

694589.94

Sample 3A

206361.93

619925.60

Sample 3B

243459.82

703275.99

Table 2: Concentrations of Test Material in Sample Solutions

Sample No.

Time shaken at ~ 30 °C (hours)

Equilibration time at 20 °C (hours)

Concentration (g/L)

Solution pH

Tin

Test Material

1

24

24

1.14 x 10^-4

6.04 x 10^-4

2.6

2

48

24

1.37 x 10^-4

7.28 x 10^-4

2.7

3

72

24

2.24 x 10^-4

1.19 x 10^- 3

2.6

Conclusions:
Interpretation of results: insoluble (< 0.1 mg/L)
Under the conditions of the study, the water solubility of the test material was determined to be less than or equal to 1.19 x 10^-3 g/L at 20.0 ± 0.5 °C.
Executive summary:

The water solubility of the test material was determined in accordance with standardised guidelines OECD 105 and EU Method A.6 using the shake flask method. Under the conditions of the study, the water solubility of the test material was determined to be less than or equal to 1.19 x 10^-3 g/L at 20.0 ± 0.5 °C.

The value obtained was higher than expected and the overall results were chosen as limit values. The analytical method is not substance specific, so some of the tin detected may have originated from more soluble impurities. Additionally the background concentration count in the blank was of an equal magnitude. It was decided not to subtract the blank, but use less than the highest sample result as a worst case scenario. As a result of this, the test material was interpreted as being insoluble.

Description of key information

Water solubility = ≤1.19 x 10^-3 g/L at 20.0 ± 0.5 °C, OECD 105, EU Method A.6, Fox 2012

Key value for chemical safety assessment

Water solubility:
0.001 g/L
at the temperature of:
20 °C

Additional information

The water solubility of the test material was determined in accordance with standardised guidelines OECD 105 and EU Method A.6 using the shake flask method. Under the conditions of the study, the water solubility of the test material was determined to be less than or equal to 1.19 x 10^-3 g/L at 20.0 ± 0.5 °C.

The value obtained was higher than expected and the overall results were chosen as limit values. The analytical method is not substance specific, so some of the tin detected may have originated from more soluble impurities. Additionally the background concentration count in the blank was of an equal magnitude. It was decided not to subtract the blank, but use less than the highest sample result as a worst case scenario. As a result of this, the test material was interpreted as being insoluble.

The study was conducted to GLP and was reported to a high standard. The study was assigned a reliability score of 1 in accordance with the criteria of Klimisch (1997) and was considered suitable as an accurate reflection of the test material.