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Diss Factsheets
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EC number: 274-040-4 | CAS number: 69563-51-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: European Commission Technical Guidance Document EUR 20268 ‘Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of chemical substances’ (2002).
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- sieving
- Remarks:
- As well as Cascade Impactor
- Type of particle tested:
- other:
- Type of distribution:
- volumetric distribution
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 12-45 (China)
- Expiration date of the lot/batch: 05 March 2019
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature in the dark - Percentile:
- D50
- Remarks on result:
- other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.
- No.:
- #1
- Size:
- < 100 µm
- Distribution:
- 15 %
- No.:
- #2
- Size:
- < 10 µm
- Distribution:
- 1.16 %
- No.:
- #3
- Size:
- < 5.5 µm
- Distribution:
- 0.18 %
- Conclusions:
- Particle size data acquired for FAT 36034/H is as follows:
Percentage of test item with an inhalable particle size <100 µm (sieve method) is 15.0 %
Percentage of test item with a thoracic particle size <10.0 µm (cascade impactor method) is 1.16 %
Percentage of test item with a respirable particle size <5.5 µm (cascade impactor method) is 0.18 % - Executive summary:
The particle size distribution of FAT36034/H TE has been determined, using a procedure designed to be compatible with the European Commission Technical Guidance Document EUR 20268 ‘Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of chemical substances’ (2002).
Particle size data acquired for FAT 36034/H TE is as follows:
Percentage of test item with an inhalable particle size <100 µm (sieve method) is 15.0 %
Percentage of test item with a thoracic particle size <10.0 µm (cascade impactor method) is 1.16 %
Percentage of test item with a respirable particle size <5.5 µm (cascade impactor method) is 0.18 %
Reference
Sieve Screening Test
The results of the sieving procedure are shown in the following table:
Measurement |
Result |
Mass of test item transferred to sieve |
11.62 g |
Mass of test item passed through sieve |
1.74 g |
Percentage of test item less than 100 µm |
15.0 % |
Cascade Impactor
The results of the cascade impactor procedure are shown in the following table:
Collection Stage |
Particle Size Range Collected (µm) |
Collected Mass (g) |
||
Determination 1* |
Determination 2 |
Determination 3 |
||
Artificial throat |
n/a |
1.09 |
0.27 |
0.26 |
Cup 1 |
>10.0 |
4.6710 |
2.6222 |
2.6426 |
Cup 2 |
5.5 to 10.0 |
0.0321 |
0.0321 |
0.0388 |
Cup 3 |
2.4 to 5.5 |
0.0012 |
0.0031 |
0.0052 |
Cup 4 |
1.61 to 2.4 |
0.0000 |
0.0000 |
0.0015 |
Cup 5 |
0.307 to 1.61 |
0.0000 |
0.0000 |
0.0011 |
Final Filter |
<0.307 |
0.0015 |
0.0014 |
0.0019 |
Total mass of collected test item |
5.7958 |
2.9288 |
2.9511 |
*Taken from cumulative weights of two determinations from the top layer.
The cumulative amounts of test item collected in the three determinations for the individual particle size cut-points are shown in the following table:
Particle Size Cut Points (µm) |
Cumulative Mass (g) |
Cumulative Percentage (%) |
||||
Determination 1* |
Determination 2 |
Determination 3 |
Determination 1* |
Determination 2 |
Determination 3 |
|
<10.0 |
0.0348 |
0.0366 |
0.0485 |
0.60 |
1.25 |
1.64 |
<5.5 |
0.0027 |
0.0045 |
0.0097 |
0.05 |
0.15 |
0.33 |
<2.4 |
0.0015 |
0.0014 |
0.0045 |
0.03 |
0.05 |
0.15 |
<1.61 |
0.0015 |
0.0014 |
0.0030 |
0.03 |
0.05 |
0.10 |
<0.307 |
0.0015 |
0.0014 |
0.0019 |
0.03 |
0.05 |
0.06 |
Mean cumulative percentage with a particle size less than 10.0 µm: 1.16%
Mean cumulative percentage with a particle size less than 5.5 µm: 0.18%
*Taken from cumulative weights of two determinations from the top layer.
Description of key information
Particle size data acquired for FAT 36034/H is as follows:
Percentage of test item with an inhalable particle size <100 µm (sieve method) is 15.0 %
Percentage of test item with a thoracic particle size <10.0 µm (cascade impactor method) is 1.16 %
Percentage of test item with a respirable particle size <5.5 µm (cascade impactor method) is 0.18 %
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.