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EC number: 233-899-5 | CAS number: 10421-48-4
In a skin irritation study, a single dose of 500 mg ferrous sulfate (moistened with water) was applied to the clipped skin (6cm2 on flank) of three male New Zealand white rabbits. The test substance was held in contact with the skin by means of a semi-occlusive dressing for four hours. Cutaneous reactions were recorded at 1, 24, 48 and 72 hours after removal of the dressing, and then daily until day 14 in order to observe the reversibility of the reactions. Residual test substance was removed by means of a dry compress. The mean score for erythema and oedema were recorded for each animal using 24, 48 and 72 hours values. Very slight or well-defined cutaneous reactions were observed after application of the test substance during 3 minutes and 1 hour. Severe cutaneous reactions were observed after application of the test substance during 4 hours. No necrosis or ulceration of the skin was observed. All lesions were reversible before the end of the 14-day observation period. It was concluded that ferrous sulfate was irritating to the skin. By read-across, iron trinitrate is also assumed to be iritating to rabbit skin.
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