Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-899-5 | CAS number: 10421-48-4
Preliminary irritation study:
The results of the epidermal exposures for the 50% test substance concentration to be tested in the main study are presented in table 1.
Based on these results, the highest test substance concentration selected for the main study was a 50% concentration.
The slight erythema of the ears as shown by the animals treated at 50% was considered not to have a toxicologically significant effect on the activity of the nodes. No oedema was observed in any of the animals examined.
All auricular lymph nodes of the animals of the experimental and control groups were considered normal in size.
No macroscopic abnormalities of the surrounding area were noted in any of the animals.
Body weights and body weight gain of experimental animals remained in the same range as controls over the study period. The slight body weight loss, noted in some animals, was considered not toxicologically significant.
The mean DPM/animal value for the experimental group treated with test substance concentrations 50% was 1052 DPM and the mean DPM/animal value for the vehicle control group was 1033 DPM.
No mortality occurred and no symptoms of systemic toxicity were observed in the animals of the main study.
The murine local lymph node assay was completed according to standard test guideline methods. The lab confirmed the validity of the methods with periodic positive control studies. Ferrous sulphate was administered in acetone:olive oil 4:1 v/v at three concentrations up to 50%.
Since there was no indication that the test substance elicits an SI ≥ 3 when tested at 50%, 202140/B was considered not to be a skin sensitizer. No EC3 value (the estimated test substance concentration that will give a SI =3) (if any) could be established. Based on these results, 202140/B would not be regarded as a skin sensitizer according to the recommendations made in the test guidelines. It does not have to be classified and has no obligatory labeling requirement for sensitization by skin contact according to the Globally Harmonized System of Classification and Labeling of Chemicals (GHS) of the United Nations (2007) and the Regulation (EC) No 1272/2008 on classification, labeling and packaging of substances and mixtures. based on read across from ferrous sulphate, iron trinitrate also does not require classification as a potential skin sensitiser.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again