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EC number: 203-777-6 | CAS number: 110-54-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1966
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as not reliable because sufficient data on the study design was not available.
Data source
Reference
- Reference Type:
- publication
- Title:
- The Identification of Contact Allergens by Human Assay
- Author:
- Kligman, AM
- Year:
- 1 966
- Bibliographic source:
- The Journal of Investigative Dermatology
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Maximization Test
- Deviations:
- yes
- Remarks:
- adopted for human volunteers
- GLP compliance:
- no
Test material
- Reference substance name:
- N-hexane
- EC Number:
- 203-777-6
- EC Name:
- N-hexane
- Cas Number:
- 110-54-3
- Molecular formula:
- C6H14
- IUPAC Name:
- hexane
- Details on test material:
- - Name of test material (as cited in study report): hexane
- Analytical Purity: assumed to be 100% active ingredients
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 25
- Sex: male
- Age: 18-50
- Race: 90% African-American
- Demographic information: inmates of Holmesburg Prison - Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST USED: patch test
ADMINISTRATION
- Type of application: occlusive
- Description of patch: Webril covered with 3 M Blenderm which is secured with Perforated Band-Aid Clear Tape
- Vehicle / solvent: no solvent was used during induction, during challenge mineral oil or petrolatum was used
- Concentrations: 100 % inducation, 25% challenge
- Volume applied: 1.0 ml inducation, 0.4 ml challenge
- Testing/scoring schedule: skin was scored immediately after each 48 hr exposure
EXAMINATIONS
- Grading/Scoring system: 0-2 positive responses was considered a weak sensitizer, 3-7 positive responses was considered a mild sensitizer, 8-13 positive responses was considered a moderate sensitizer, 14-20 positive responses was considered a strong sensitizer, 21-25 positive responses was considered an extreme sensitizer
Results and discussion
- Results of examinations:
- NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions: 0
- Number of subjects with negative reactions: 25
Applicant's summary and conclusion
- Conclusions:
- The test substance is not sensitizing.
- Executive summary:
This study examined the skin sensitization potential of hexane. 1.0 ml of test substance was placed on the extremities of 25 male volunteers, and covered occlusively. The induction patches were left in place for 48 hrs. After a 24 hr interval, the exposure was repeated for another 48 hrs. This was done for a total of 5 exposures. A challenge exposure was then done using a 25% concentration of test substance. The challenge exposure was 48 hrs. No irritation was seen in any of the test subjects. The test substance is not sensitizing.
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