Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-777-6 | CAS number: 110-54-3
The worker long-term exposure DNELs for systemic effects are based on the Indicative Occupational Exposure Limit (IOEL) for n-hexane. The inhalation DNEL is the IOEL, the NOAEC of 225 mg/m³ based on AF of 3. The assessment factor used has been derived by combining all the contributing assessment factors, which include allometric scaling, worker population, exposure duration, dose-response and quality of database.
The study of Governa et al. (1987) was used by the EC Scientific Committee for Occupational Exposure Limits to establish the IOELfor n-hexane. This study indicated that electroneuroyographic abnormalities occurred in workers with concentrations of 2,5-hexanedione in post-shift urine greater than 7.5 mg/L, which corresponded to an 8-hour time weighted average of about 70 ppm (250 mg/m3) and this is a LOAEL for effects on the peripheral nervous system. An assessment factor of 3 was applied to account for intraspecies differences among workers.
The dermal DNEL was calculated by multiplying the IOEL by 10 m2(the volume of air breathed) and divided by 70 kg (the average worker body weight). An assessment factor of three was applied. The assessment factor used has been derived by combining all the contributing assessment factors, which include allometric scaling, worker popultion, exposure duration, dose-response and quality of database.
n-Hexane is not classified as acutely toxic according to OECD GHS guidelines; therefore, acute / short-term DNELs were not derived.
n-Hexane exposure at levels significantly higher than the systemic DNELs results in local effects (nasal lesions). The systemic DNELs are protective for both systemic and local effects, therefore DNELs for local effects were not derived.
The general population long-term exposure DNELs for systemic effects are based on the Indicative Occupational Exposure Limit (IOEL) for n-hexane. The inhalation DNEL is the IOEL multiplied by 10/20 to correct for differences between worker and general population ventilation rates, 5/7 to correct for days per week potentially exposed, and 3/5 to use an assessment factor of 5 for intraspecies differences. The dermal and oral DNELs were calculated by multiplying the inhalation DNEL by 20 m3 (the volume of air a person breathes in a day) and dividing by 60 kg (average body weight of general population).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again