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Description of key information

One human epidemiological study was identified for C6 aliphatics, high n-hexane (Wang, 1986; Klimisch score =2).

Additional information

In a key epidemiological study researchers evaluated a group of 59 press proofing workers from 16 factories who were employed for at least 2 months (Wang, 1986; Klimisch score =2). All but four of these workers had regular contact with solvents in the process of cleaning the rollers. Two exposure measures using personal air samplers were taken in 14 of the 16 factories. Referent neurological data was also collected from workers and healthy individuals. MCVs were also collected from workers exposed to n-hexane.

The neurological examination identified 15 workers with polyneuropathy and two ashymptomatic workers with abnormal MCVs. All but one of the workers were employed in factories that used solvents with n-hexane concentrations in excess of 50%. 

No association was found with length of employment, statistically significant associations existed between frequency of polyneuropathy and abnormal MCV and n-hexane concentration in the cleaning solvents and between the frequency of polyneuropathy and n-hexane air concentrations. However, a significant reduction in the MCV was found among workers exposed to air concentrations less than 25 ppm, a result that the authors considered to be related to the prolonged exposure due to overtime work.