Registration Dossier
Registration Dossier
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EC number: 203-466-5 | CAS number: 107-13-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Published mechanistic study reporting acute LD50 values
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute toxicity of some synthetic cyanogens in rats: Time-dependent cyanide generation and cytochrome oxidase inhibition in soft tissues after sub-lethal oral intoxication
- Author:
- Rao P, Singh P, Kumar Yadav S, Gujar NL & Bhattacharya R
- Year:
- 2 013
- Bibliographic source:
- Food and Chemical Toxicology 59: 595–609
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Dixon’s up and down method
- GLP compliance:
- no
- Remarks:
- published study
- Test type:
- up-and-down procedure
- Limit test:
- no
Test material
- Reference substance name:
- Acrylonitrile
- EC Number:
- 203-466-5
- EC Name:
- Acrylonitrile
- Cas Number:
- 107-13-1
- Molecular formula:
- C3H3N
- IUPAC Name:
- prop-2-enenitrile
Constituent 1
- Specific details on test material used for the study:
- Not reported
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- Rats were gavaged with acrylonitrile
- No. of animals per sex per dose:
- 6-8 rats were used in total
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 95.1 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 81.7 - <= 110.6
- Remarks on result:
- other:
- Remarks:
- An acute oral LD50 of 95.1 (81.7 -110.6) mg/kg bw is reported.
Any other information on results incl. tables
An acute oral LD50 of 95.1 (81.7 -110.6) mg/kg bw is reported.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- An acute oral LD50 of 95.1 (81.7 -110.6) mg/kg bw is reported.
- Executive summary:
The oral LD50 of acrylonitrile was investigated preliminary to mechanistic investigations. 6 -8 female Wistar rats were administered acrylonitrile by gavage according to Dixon’s up and down method. An acute oral LD50 of 95.1 (81.7 -110.6) mg/kg bw is reported. This value is consistent with other data.
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