Registration Dossier
Registration Dossier
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EC number: 231-668-3 | CAS number: 7681-52-9
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Public available literature without indication of guideline and GLP, only basic information available
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Public avaialble literature. No guideline indicated. For details on method see materials and methods section in IUCLID5 dossier.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium hypochlorite
- EC Number:
- 231-668-3
- EC Name:
- Sodium hypochlorite
- Cas Number:
- 7681-52-9
- Molecular formula:
- ClO.Na
- IUPAC Name:
- sodium hypochlorite
- Details on test material:
- sodium hypochlorite
Constituent 1
Test animals
- Species:
- mouse
Administration / exposure
- Route of administration:
- other: inhalation
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- other: RD50
- Effect level:
- 4.1 ppm
- Remarks on result:
- other: based on free chlorine
Any other information on results incl. tables
The RD50 for an atmosphere of chlorine has been estimated as 6.7 ppm and an atmosphere of sodium hypochlorite (based on free chlorine) as 4.1 ppm. The similarity of the results show that the irritancy of the sodium hypochlorite is associated with the chlorine content of the material. This test measures only respiratory ( sensory ) irritancy and does not take into account other forms of toxicity.
Applicant's summary and conclusion
- Executive summary:
The RD50 for an atmosphere of chlorine has been estimated as 6.7 ppm and an atmosphere of sodium hypochlorite (based on free chlorine) as 4.1 ppm. The similarity of the results show that the irritancy of the sodium hypochlorite is associated with the chlorine content of the material. This test measures only respiratory ( sensory ) irritancy and does not take into account other forms of toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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