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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1954
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This study was conducted prior to GLP and test guidelines, but sufficient data is available for interpretation of results
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1954
Report date:
1954

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
None
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium chloride
EC Number:
231-598-3
EC Name:
Sodium chloride
Cas Number:
7647-14-5
Molecular formula:
ClNa
IUPAC Name:
sodium chloride
Details on test material:
- Name of test material (as cited in study report): Sodium Chloride
- Common name: Table salt
- Physical state: White solid granules
- Soluble: Water

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
No data

Test system

Type of coverage:
not specified
Preparation of test site:
other: intact and abraded
Vehicle:
water
Remarks:
for 5%, 10%, 20% and 50 % NaCl solution
Controls:
not specified
Amount / concentration applied:
TEST MATERIAL
- Concentration (if solution): 5%, 10%, 20% and 50 % and 100% NaCl
Duration of treatment / exposure:
No data
Observation period:
No data
Number of animals:
No data
Details on study design:
Please see the table below.

Results and discussion

In vivo

Irritant / corrosive response data:
When in contact with the intact skin, sodium chloride causes no response, either in undiluted form or in solution. However, abraded skin may be appreciably irritated depending upon the concentration of the salt solution. Strong solutions (20% or better) result in scab and scar formation after a few applications. Weaker solutions (10% or 5%) produce slight irritation which delays healing without scarring.
Other effects:
None

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: other: As specified in the report based on intact skin
Conclusions:
When in contact with the intact skin, sodium chloride causes no response, either in undiluted form or in solution. However, abraded skin may be appreciably irritated depending upon the concentration of the salt solution. Strong solutions (20% or better) result in scab and scar formation after a few applications. Weaker solutions (10% or 5%) produce slight irritation which delays healing without scarring.
Executive summary:

When in contact with the intact skin, sodium chloride causes no response, either in undiluted form or in solution. However, abraded skin may be appreciably irritated depending upon the concentration of the salt solution. Strong solutions (20% or better) result in scab and scar formation after a few applications. Weaker solutions (10% or 5%) produce slight irritation which delays healing without scarring.