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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Toxicological information


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Administrative data

Description of key information

Calcium chloride is not genotoxic in vivo. Calcium and chloride are both essential nutrients for humans and a daily intake of more than 1000 mg for each of the ions is recommended. As for healthy humans, the tolerable upper intake level for calcium is set at 2500 mg per day (equivalent to 6.9 g CaCl2per day) [1]. For chloride, the reference nutrient intake is set at 2500 mg/day (equivalent to 3.9 g CaCl2per day) [2].

The safety of the use of calcium chloride as a food additive was recently re-evaluated the EFSA Panel on Food Additives and Flavourings (Scientific opinion dated 6 June 2019, doi: 10.2903/j.efsa.2019.5751). The assessment confirmed that there is no concern with respect to carcinogenicity.

Based on this information, it is concluded that the substance is not carcinogenic and the performance of a carcinogenicity study for calcium chloride is not indicated.

Key value for chemical safety assessment

Justification for classification or non-classification

Additional information