Calcium chloride

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:

direct observations: clinical cases, poisoning incidents and other

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Published in a peer-reviewed paper, limited reporting, but otherwise acceptable for assessment.

Data source

Reference

Reference Type:

publication

Title:

Inhalation of calcium chloride aerosols in complex therapy of pulmonary tuberculosis.

Author:

Vinnikov PL, Slepova RI, Sataev IF

Year:

1962

Bibliographic source:

Kazan Med Zh. , 4, 7-9

Materials and methods

Study type:

other: tuberculosis patients treatment

Endpoint addressed:

acute toxicity: inhalation

Principles of method if other than guideline:

Sixty five tuberculosis patients (51 males, 14 females; age from below 30 till over 50) were treated with aerosol inhalations of 2-5% aqueous solution of calcium chloride. The number of inhalations varied from below 10 (24 patients), till over 30 (2 patients). Clinical signs are reported.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Calcium chloride

EC Number:

233-140-8

EC Name:

Calcium chloride

Cas Number:

10043-52-4

Molecular formula:

CaCl2

IUPAC Name:

calcium dichloride

Details on test material:

No data.

Method

Type of population:

other: tuberculosis patients

Subjects:

- Number of subjects exposed: 65
- Sex: 51 males, 14 females
- Age: below 30: 17, from 31 to 50: 39, over 50: 9
- Race: unknown
- Demographic information: unknown
- Known diseases: tuberculosis

Ethical approval:

not specified

Route of exposure:

inhalation

Reason of exposure:

intentional

Exposure assessment:

not specified

Examinations:

- Other: symptomatic assessment (cough duration and frequency, sputum expellance, sputum nature etc.)

Results and discussion

Clinical signs:

Several patients reported irritation of mucos membranes of pharinx and throat and unpleasant sensation in mouth already after the first inhalations. However, the frequency of such cases was described as minor by the authors. Overall calcium chloride inhalations were said to have beneficiary effects on disease symptoms (improved quality of spatum, decreased amounts of spatum, improved ease of spatum expellance, decreased frequency of coughing).

Outcome of incidence:

Several patients reported irritation of mucos membranes of pharinx and throat and unpleasant sensation in mouth already after the first inhalations. However, the frequency of such cases was described as minor by the authors. Overall calcium chloride inhalations were said to have beneficiary effects on disease symptoms (improved quality of spatum, decreased amounts of spatum, improved ease of spatum expellance, decreased frequency of coughing).