Registration Dossier
Registration Dossier
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EC number: 233-140-8 | CAS number: 10043-52-4
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Primary mutagenicity screening of food additives currently used in Japan
- Author:
- Ishidate, M., Jr., Sofumi, T., Yoshikawa, K., Hayashi, M.,|Nohmi, T., Sawada, M. and Matsuoka, A.
- Year:
- 1 984
- Bibliographic source:
- Fd Chem. Toxic., 22, 623-636
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 473 (In Vitro Mammalian Chromosome Aberration Test)
- Deviations:
- yes
- Remarks:
- no test with metabolic activation
- GLP compliance:
- not specified
- Type of assay:
- in vitro mammalian chromosome aberration test
Test material
- Reference substance name:
- Calcium chloride
- EC Number:
- 233-140-8
- EC Name:
- Calcium chloride
- Cas Number:
- 10043-52-4
- Molecular formula:
- CaCl2
- IUPAC Name:
- calcium dichloride
- Details on test material:
- No data.
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: Chinese hamster fibroblast cell line CHL
- Metabolic activation:
- without
- Test concentrations with justification for top dose:
- max. 4 mg/plate
Results and discussion
Test results
- Species / strain:
- Chinese hamster lung fibroblasts (V79)
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks on result:
- other: all strains/cell types tested
Applicant's summary and conclusion
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