Registration Dossier
Registration Dossier
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EC number: 233-140-8 | CAS number: 10043-52-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline study according to GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Calcium chloride
- EC Number:
- 233-140-8
- EC Name:
- Calcium chloride
- Cas Number:
- 10043-52-4
- Molecular formula:
- CaCl2
- IUPAC Name:
- calcium dichloride
- Test material form:
- solid: crystalline
- Details on test material:
- Test substance: Anhydrous calcium chloride (CaCl2), a white powder,
prepared from calcium chloride dihydrate flakes (Batch No.
Couillet 8/OCT/1985 FLAKES). The test material was solid
at the application time. Upon analysis sample contained:
97.0% CaCl2, 2.2% NaCl and 0.11% Ca(OH)2.
Constituent 1
Test animals
- Species:
- rabbit
Test system
- Type of coverage:
- occlusive
- Amount / concentration applied:
- undiluted
- Duration of treatment / exposure:
- 4 hour(s)
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Score:
- 0
- Remarks on result:
- other: no effects seen
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
Any other information on results incl. tables
- Table 1: Scores of the skin reaction of the rabbit after
application of anhydrous calcium chloride at different times after patch removal.
-----------------------------------------------------
Animal Symptom score after
No. ----------------------------------------------
30-60 24 48 72
minutes hours hours hours
-----------------------------------------------------
1 erythema 0 0 0 0
oedema 0 0 0 0
-----------------------------------------------------
2 erythema 0 0 0 0
oedema 0 0 0 0
-----------------------------------------------------
3 erythema 0 0 0 0
oedema 0 0 0 0
-----------------------------------------------------
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Classification: not irritating
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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