Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

Glycerol, propoxylated is an essentially non-volatile liquid (vapour pressure 6 x 10-2 hPa at 20ºC), at room temperature, fully miscible with water and with a log P of 1.0 – 1.6 (as measured on commercial material). There are no experimental studies on the toxicokinetics of propoxylated glycerol. The information on the toxicokinetics of glycerol, propoxylated, 1-6.5 mol and higher oligomers is based on the information for glycerol and for propane-1, 2-diol (propylene diol) and oxydipropanol and [(methylethylene)bis(oxy)]dipropanol. Additional information is derived from studies on the absorption of hydrocarbons and the acute toxicity data for higher molecular weight polyols that use glycerol as initiator.

Discussion on bioaccumulation potential result:

Glycerol is solely a core substance (initiator). However, it is structurally related to propane-1,2-diol (both are C3) and there are similarities in the metabolism of fatty acid esters of both substances by the intestine. There are three free alcohol groups available for formation of the NLP polyols, so the likelihood is that the side chains will be mainly of one or two units, with some of three units. The information on the toxicokinetics of glycerol, propoxylated, 1-6.5 mol (the NLP polyol), and higher oligomers/polymers generally, is based on the information for glycerol, for triglycerides (fats) and for propane 1,2-diol and oligomers. Additional information is derived from studies on the absorption of hydrocarbons. There is some further information in Patty which has also been incorporated into this assessment. In addition, some predictions can be made from the physicochemical and toxicological information on the oligomers