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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
Screening test; 2 animals per dose group, summarized description of the method used and the results.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1956
Report date:
1956

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: dermal toxicity screening
Principles of method if other than guideline:
Screen for dermal toxicity/absorption, 2 animals per group
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Methacrylic acid
EC Number:
201-204-4
EC Name:
Methacrylic acid
Cas Number:
79-41-4
Molecular formula:
C4H6O2
IUPAC Name:
methacrylic acid
Test material form:
liquid
Specific details on test material used for the study:
Purity not specified, typically >= 98 %

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
water
Details on dermal exposure:
Substance prepared 50% in water
Doses:
0.5, 1.0 and 2.0 g/kg.
No. of animals per sex per dose:
2/group

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
>= 500 - <= 1 000 mg/kg bw
Mortality:
Dose (mg/kg)    mortality
500              0/2
1000             2/2
2000             2/2
Clinical signs:
other: At 500 mg/kg (50 % solution in water)  there was slight weight loss and the skin was severely burned. At 1000 mg/kg the animals died overnight.
Other findings:
Toxicity due to dermal corrosion.

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
In a valid screening study, the acute dermal LD50 in rabbits of MAA was 500-1000 mg/kg bw.
Executive summary:

In a valid screening study, the acute dermal LD50 in rabbits of MAA was 500-1000 mg/kg bw.