Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: dermal

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Administrative data

short-term repeated dose toxicity: dermal
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
Justification for type of information:
In accordance with Column 1 of REACH Annex VIII, repeated dose toxicity testing on the most appropriate route of administration shall be conducted having regard to the likely route of human exposure. For the registered substance, inhalation is deemed to be the most likely route of human exposure and therefore repeated dose toxicity testing via the dermal route is not considered scientifically necessary. The physiochemical properties of MnO2 suggest it is unlikely to be absorbed through the skin. In addition, MnO2 has a very low solubility in water, which coupled with its physical inorganic nature (powder) means that it is unlikely to be readily absorbed through the skin and therefore it is highly unlikely that it would be toxic via the dermal route. Furthermore, on animal welfare grounds, adaptation is appropriate in consideration of the extensive use of experimental animals that would be required.

Data source

Materials and methods

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion