Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The skin sensitisation potential of 2-propanol was assessed in a study performed according to OECD Guidelines for the Testing of Chemicals No. 406 and in compliance with GLP in male and female Hartley guinea pigs (Hill Top Research, Inc, 1980). In the study, 10 animals/sex comprised the 2-propanol test group and 5 animals/sex comprised the control group.  The epicutaneous induction was carried out with 0.4 mL of undiluted 2-propanol (100% w/w) at the upper left quadrant of the back of the test group animals (3 induction exposures during 3 weeks, 6 hours with webril paches under occlusion each).  The challenge exposure also was conducted with 0.4 mL of undiluted 2-propanol at the lower left quadrant of the back of the test group and control group animals. Skin reactions were observed and recorded 1 hour after dermal induction and 24 and 48 hours after the challenge exposure. No positive skin reactions were observed in all animals 24 or 48 hours after challenge. Under the experimental conditions and according to the epicutaneous method of Buehler, no cutaneous reactions attributable to the sensitisation potential of 2-propanol were observed in guinea-pigs.  Therefore, the results of this study demonstrated that 2-propanol showed no evidence of contact skin sensitisation in guinea pigs

Migrated from Short description of key information:
Skin sensitisation of iso propyl alcohol has been tested on guinea pigs. The test was performed under GLP according to test guidelines (OECD 406, Buehler method) and has demonstrated that the compound is not sensitizing via skin.

Respiratory sensitisation

Endpoint conclusion
Additional information:

The substance does not meet the criteria for classification and labelling for this endpoint, as set out in Regulation (EC) No. 1272/2008.

Justification for classification or non-classification