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EC number: 200-661-7
CAS number: 67-63-0
The skin sensitisation of isopropyl alcohol has been tested in guinea
pigs. In a study conducted according to OECD Test Guideline 406, Buehler
method, and in compliance with GLP, it was that isopropyl alcohol is not
sensitizing via skin.
One group of 20 test animals was treated with undiluted Isopropyl
alcohol for a period of 6 hours weekly for 3 induction exposures. The
test animals and control animals were challenged with undiluted
Isopropyl alcohol. No skin reactions were observed in the test and
control animals therefore, it was concluded that Isopropyl alcohol is
not a sensitizer.
sensitisation potential of propan-2-ol was assessed in a study performed
according to OECD Test Guideline 406 and in compliance with GLP in male
and female Hartley guinea pigs (Hill Top Research, Inc, 1980). In the
study, 10 animals/sex comprised the propan-2-ol test group and 5
animals/sex comprised the control group. The epicutaneous induction was
carried out with 0.4 mL of undiluted propan-2-ol (100% w/w) at the upper
left quadrant of the
back of the test group animals (3 induction exposures during 3 weeks,
each exposure for 6 hours with Webril patches under occlusion). The
challenge exposure also was conducted with 0.4 mL of undiluted
propan-2-ol at the lower left quadrant of the back of the test group and
control group animals. Skin reactions were observed and recorded 1 hour
after dermal induction and 24 and 48 hours after the challenge
exposure. No positive skin reactions were observed in all animals 24 or
48 hours after challenge. Under the experimental conditions and
according to the epicutaneous method of Buehler, no cutaneous reactions
attributable to the sensitisation potential of propan-2-ol were observed
in guinea-pigs. Therefore, the results of this study demonstrated that
propan-2-ol showed no evidence of contact skin sensitisation in guinea
The substance does not meet the criteria for classification and
labelling for skin sensitisation according to Regulation (EC) No.
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