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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Reference
Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
other: Two prediction approaches, i.e. the QSAR model battery and QSAR Toolbox category approach were applied. This enabled a justified conclusion and derivation of a reliable and adequate BCF for TMPTA by weight of evidence.
Adequacy of study:
weight of evidence
Study period:
November 2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
A Weight of Evidence approach (WoE) was used, because information from a single data source was not sufficient enough to establish an adequate and reliable BCF result. Secondly, the Weight of Evidence approach was performed to avoid unnecessary animal testing in fish.
This study integrated two lines of evidence, i.e. the QSAR model battery and QSAR Toolbox category approach. Both approaches resulted in low log BCFs in the range of 1.24 – 2.09. Aiming for a conservative log BCF for TMPTA, the final log BCF was determined as 2.09.
Qualifier:
no guideline followed
Principles of method if other than guideline:
The BCF was based on QSAR methods
GLP compliance:
no
Specific details on test material used for the study:
Not relevant - the BCF was calculated
Details on test organisms:
Fish
Details on estimation of bioconcentration:
A Weight of Evidence approach (WoE) was used, because information from a single data source was not sufficient enough to establish an adequate and reliable BCF result. Secondly, the Weight of Evidence approach was performed to avoid unnecessary animal testing in fish.
This study integrated two lines of evidence, i.e. the QSAR model battery and QSAR Toolbox category approach. Both approaches resulted in low log BCFs in the range of 1.24 – 2.09. Aiming for a conservative log BCF for TMPTA, the final log BCF was determined as 2.09.
The evidence of existing experimental log BCF data in the range of 1.1 – 2.39 of structural similar substances supported the determined log BCF value of 2.09 for TMPTA.
The bioaccumulation factor of 2.09 for TMPTA was considered reliable and adequate for the environmental hazard assessment based on available experimental data and state-of-the-art of in-silico methods to date.
Key result
Type:
BCF
Value:
123 L/kg
Basis:
whole body w.w.
Remarks on result:
other:
Remarks:
The evidence of existing experimental log BCF data in the range of 1.1 – 2.39 of structural similar substances supported the determined log BCF value of 2.31 for TMPTA.
Validity criteria fulfilled:
not applicable
Conclusions:
A Weight of Evidence approach (WoE) was used, because information from a single data source was not sufficient enough to establish an adequate and reliable BCF result. Secondly, the Weight of Evidence approach was performed to avoid unnecessary animal testing in fish.
This study integrated two lines of evidence, i.e. the QSAR model battery and QSAR Toolbox category approach. Both approaches resulted in low log BCFs in the range of 1.24 – 2.09. Aiming for a conservative log BCF for TMPTA, the final log BCF was determined as 2.09. The final BCF was determined at 123.
The evidence of existing experimental log BCF data in the range of 1.1 – 2.39 of structural similar substances supported the determined log BCF value of 2.09 for TMPTA.
The bioaccumulation factor of 2.09 for TMPTA was considered reliable and adequate for the environmental hazard assessment based on available experimental data and state-of-the-art of in-silico methods to date.
Executive summary:

A Weight of Evidence approach (WoE) was used, because information from a single data source was not sufficient enough to establish an adequate and reliable BCF result. Secondly, the Weight of Evidence approach was performed to avoid unnecessary animal testing in fish.

This study integrated two lines of evidence, i.e. the QSAR model battery and QSAR Toolbox category approach. Both approaches resulted in low log BCFs in the range of 1.24 – 2.09. Aiming for a conservative log BCF for TMPTA, the final log BCF was determined as 2.09. The final BCF was determined at 123.

The evidence of existing experimental log BCF data in the range of 1.1 – 2.39 of structural similar substances supported the determined log BCF value of 2.09 for TMPTA.

The bioaccumulation factor of 2.09 for TMPTA was considered reliable and adequate for the environmental hazard assessment based on available experimental data and state-of-the-art of in-silico methods to date.

Description of key information

A Weight of Evidence approach (WoE) was used, because information from a single data source was not sufficient enough to establish an adequate and reliable BCF result. This study integrated two lines of evidence, i.e. the QSAR model battery and QSAR Toolbox category approach. Both approaches resulted in low log BCFs in the range of 1.24 – 2.09. Aiming for a conservative log BCF for TMPTA, the final log BCF was determined as 2.09 (BCF = 123).

Key value for chemical safety assessment

BCF (aquatic species):
123 L/kg ww

Additional information

Both approaches resulted in low log BCFs in the range of 1.24 – 2.09. Aiming for a conservative log BCF for TMPTA, the final log BCF was determined as 2.09 (BCF = 123).