Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-325-2 | CAS number: 81-11-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
not mutagenic
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
The substance was evaluated for its mutagenic and genotoxic potential in vitro. Overall the data do not indicate any mutagenic or genotoxic potential of the substance.
in vitro-Tests:
No evidence for a mutagenic effect was obtained in Salmonella strains TA 98, TA 100, TA 1535, TA 1537 and E. coli WP2 uvr A in experiments with and without microsomal activation.
No evidence for a clastogenic effect in Chinese Hamster ovary cells was obtained.
No induction of SCE's in Chinese Hamster ovary cells occured.
The studies were found to be adequate to fufill the purposes of this endpoint.
Short description of key information:
in vitro: negative in Ames Test with Salmonella strains TA 98, TA 100, TA 1535, TA 1537 and E. coli WP2 uvr A (with and without microsomal activation)
in vitro: negative in Chromosome Aberration Test in Chinese Hamster ovary cells
in vivo: negative in SCE-Assay in Chinese Hamster ovary cells
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
There are conclusive but not sufficient data for classification of the substance with regard to mutagenicity.
The substance is not classified for this endpoint in accordance to the CLP Regulation (EC) No 1272/2008
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
