Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data came from the HPV dossier (IUCLID 4 file) on CAS No. 81-11-8 that was posted on the OECD website.

Data source

Reference
Reference Type:
publication
Title:
Uterotropic action in rat of amsonic acid and three of its synthetic precursors.
Author:
Smith ER and Quinn MM
Year:
1992
Bibliographic source:
J. Toxicol. Environ. Health. 36(1), 13-25.

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
female
Details on test animals and environmental conditions:
no data

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Details on exposure:
no data
Doses:
3000 mg/kg bw
1000 mg/kg bw
No. of animals per sex per dose:
3000 mg/kg bw: 6
1000 mg/kg bw: 15
Control animals:
not specified
Details on study design:
no data
Statistics:
no data

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
ca. 3 000 mg/kg bw
Mortality:
Two out of six animals given 3000 mg/kg i.p. died within 24 hours of
treatment. None of the 15 animals given 1000 mg/kg died.
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Applicant's summary and conclusion