Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-561-3 | CAS number: 980-26-7
The purpose of this study was to assess the acute inhalation toxicity of the test item when administered to rats for a single 4-hour period.
One group of five male and five female albino rats [HanBrl:WIST(SPF)], were exposed by noseonly, flow-past inhalation to the test item at mean aerosol concentrations of 3.055 ± 0.068 (n=5) mg/L air (gravimetrically determined). Two gravimetric measurements of particle size distribution during the exposure produced mass median aerodynamic diameters and geometric standard deviations (GSD) of 2.83 µm (GSD 4.04) and 2.64 µm (GSD 3.93), respectively.
All animals were observed for clinical signs and mortality during and following the inhalation exposure, i.e. over a 15-day observation period. Body weights were recorded prior to exposure on test day 1, and during the observation period on test days 4, 8 and 15. All animals were sacrificed and necropsied on day 15.
The ranges of temperature, relative humidity, oxygen content and particle size measured during the exposure were satisfactory for a study of this type.
There were no spontaneous deaths.
All animals showed rales, decreased spontaneous activity, hunched posture, tachypnea and ruffled fur on the day of exposure and the two following days in individually variable extent.
Four females showed a slight transient body weight loss between Day 1 and Day 4. All other animals gained body weight as expected.
There were no macroscopic pathology findings in any of the animals.
In conclusion, at the highest technically achievable aerosol concentration of the test item of 3.055 mg/L air, none of the ten exposure animals died (LC0 = 3.055 mg/L). Based on the lack of lethal effects or severe clinical symptoms indicating a life-threatening or moribund state, it may be reasonably assumed that the LC50 for the test item is likely to be greater than 5 mg/L air.
Therefore, the test item has not to be classified as acutely toxic by the inhalation route according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again