Registration Dossier
Registration Dossier
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EC number: 213-561-3 | CAS number: 980-26-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary source
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Acute toxicity data
- Author:
- Anon.
- Year:
- 1 996
- Bibliographic source:
- Journal of the American College of Toxicology, Vol. 15, Suppl. 1, S22-S23
Materials and methods
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- 5,12-dihydro-2,9-dimethylquino[2,3-b]acridine-7,14-dione
- EC Number:
- 213-561-3
- EC Name:
- 5,12-dihydro-2,9-dimethylquino[2,3-b]acridine-7,14-dione
- Cas Number:
- 980-26-7
- Molecular formula:
- C22H16N2O2
- IUPAC Name:
- 2,9-dimethyl-5,7,12,14-tetrahydro-5,12-diazapentacene-7,14-dione
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- water
- Duration of exposure:
- 24 h
- Doses:
- 3 g/kg of the test article (in the form of an aqueous slurry)
- No. of animals per sex per dose:
- 2 males and 2 females
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Remarks on result:
- other: no animals died within the 14 day observation period
Any other information on results incl. tables
No mortality was observed at 3 g/kg and no unusual behavioral, systemic reactions or gross pathologic alterations were observed. Body weight gains were within normal range of growth.
Applicant's summary and conclusion
- Conclusions:
- Pigment Red 122 caused no mortality in male and female rabbits after a single dermal application of 3000 mg/kg bw.
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