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EC number: 213-561-3 | CAS number: 980-26-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 October 2006
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Test procedure according to method of Analytical Expert Group ETAD (Ecological and Toxicological Association of Dyes and Organic Pigment Manufacturer)
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- test procedure similar to OECD 105
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- modified taking into account the very low solubility of the test substance
- Principles of method if other than guideline:
- The method for the determination and analytical investigation is according to the method that was agreed upon at the "Analytical Experts Meeting" of ETAD (Basel) on January 12, 2005.
- GLP compliance:
- no
- Type of method:
- flask method
- Water solubility:
- 5.6 µg/L
- Temp.:
- 24 °C
- pH:
- ca. 7
- Remarks on result:
- other: mean of 3 measurements
- Conclusions:
- the test substance is practically insoluble in water (< 0.1 mg/L)
individual results: 3.0 µg/L - 5.1 µg/L - 8.7 µg/L
mean: 5.6 µg/L
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Test procedure according to method of Analytical Expert Group ETAD (Ecological and Toxicological Association of Dyes and Organic Pigment Manufacturer)
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: Analytical Expert Group ETAD
- Principles of method if other than guideline:
- Test procedure according to method of Analytical Expert Group ETAD (Ecological and Toxicological Association of Dyes and Organic Pigment Manufacturer)
- GLP compliance:
- no
- Medium:
- n-octanol
- Solubility:
- 0.84 mg/L
- Temp.:
- 24 °C
- Remarks on result:
- other: mean of three measurements
individual results: 0.82 mg/L - 0.85 mg/L - 0.84 mg/L
mean: 0.84 mg/L
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: ETAD Analytical Expert Group
- Version / remarks:
- method for substances with very low solubility in both, water and n-octanol
- Principles of method if other than guideline:
- Based on the determined solubilities in water and n-octanol the partition coefficient was calculated.
- GLP compliance:
- no
- Type of method:
- estimation method (solubility ratio)
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 5,12-dihydro-2,9-dimethylquino[2,3-b]acridine-7,14-dione
- EC Number:
- 213-561-3
- EC Name:
- 5,12-dihydro-2,9-dimethylquino[2,3-b]acridine-7,14-dione
- Cas Number:
- 980-26-7
- Molecular formula:
- C22H16N2O2
- IUPAC Name:
- 2,9-dimethyl-5,7,12,14-tetrahydro-5,12-diazapentacene-7,14-dione
- Test material form:
- solid: nanoform
Constituent 1
Study design
- Analytical method:
- photometric method
Results and discussion
Partition coefficientopen allclose all
- Type:
- Pow
- Partition coefficient:
- 150
- Temp.:
- 24 °C
- pH:
- ca. 7
- Type:
- log Pow
- Partition coefficient:
- 2.2
- Temp.:
- 24 °C
- pH:
- ca. 7
Any other information on results incl. tables
Partition coefficient values (n-octanol/water) are difficult to measure for chemicals with low solubility in both water and octanol, which applies to a variety of pigments.
The water and n-octanol solubility values of individual pigments could be determined with an analytical method that was agreed upon at the Analytical Experts Meeting of ETAD (Basel) on 12 January 2005 (ETAD: The Ecological and Toxicological Association of Dyes and Organic Pigments Manufacturers).
According to the “Guidance on Information Requirements and Chemical Safety Assessment” (chapter R.7.1.8; ECHA, 2008) and according to Regulation (EC) No 440/2008 (chapter A.8), such a calculation is an accepted method for the estimation of partition coefficients of substances for which other methods (according to e.g. OECD TG 107 and 117) are not feasible or unsuitable.
Pow and log Pow were calculated from equilibrium concentrations in n-octanol (see section 4.9) and in water (see section 4.8) with the following equation: Pow = equilibrium concentration in n-octanol / equilibrium concentration in water. Pow values were converted to log Pow values by taking the decadic logarithm.
Both solubilites were determined with the same test material batch and at the same temperature
Applicant's summary and conclusion
- Conclusions:
- The test substance has a log Pow of 2.2.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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