Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
10 October 2006
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2006
Report Date:
2006

Materials and methods

Principles of method if other than guideline:
About 5 mg of the test sample were suspended in 30 ml octanol saturated water (bi dest.) in a sample flask and were shaken for two hours at 30°C with 400 rpm. Then shaking was continued at ambient temperature (24 ¿ 25°C) for 70 hours, followed by filtration through a 0.05 µm membrane filter.
The resulting clear solution was measured by UV-vis spectrometry and the absorption was determined at lambda 599 nm. The determination was repeated three times.
A similar procedure was used for water saturated octanol, apart that filtration was through a 0.2 µm membrane filter and then through two identical filters and that absorption was determined at lambda-max 539 nm.

Calibration for determination of concentration of the samples: calibration curve of Pigment Red 122 in TFA
GLP compliance:
not specified
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent

Study design

Analytical method:
photometric method

Results and discussion

Partition coefficientopen allclose all
Type:
Pow
Partition coefficient:
150
Temp.:
24 °C
pH:
ca. 7
Type:
log Pow
Partition coefficient:
2.2
Temp.:
24 °C
pH:
ca. 7

Any other information on results incl. tables

The solubility of the sample Pigment Red 122 in octanol saturated water at ambient temperature, determined under the conditions as mentioned below, is 5.6 µg per liter (mean, n=3, range: 3.0 -8.7 µg/L, sigma = 2.9).

The solubility of the sample Pigment Red 122 in water saturated octanolat ambient temperature, determined under the conditions as mentioned below, is  0.84 mg per liter (mean, n=3, range: 0,82 -0.85 mg/L,

sigma = 0.02).

The temperature given is 24 -25°C (24°C entered above).

Applicant's summary and conclusion

Conclusions:
The test substance has a log Pow of 2.2.
Executive summary:
The log Pow of the test substance was calculated from the solubilities in octanol saturated water and in water saturated octanol. The log Pow at 24-25°C was 2.2.