Registration Dossier

Administrative data

Description of key information

- An up to date acute oral toxicity study is available that reports no toxicity at the maximum dose of 2000 mg/kg bw.
- No studies on dermal toxicity are available.
- A set of non-standard studies with single inhalation exposure are available, but not suitable for setting a LC50.
- Only airborne exposures to soluble beryllium compounds are associated with acute beryllium disease. Exposure to beryllium metal has not been found to be associated with acute or short-term respiratory reactions.
Eisenbud M. The Standard for Control of Chronic Beryllium Disease. Appl Occup Environ Hyg 13(1): 25–31 (1998).

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50

Additional information

Justification for classification or non-classification

- oral toxicity: Be metal is non-toxic via the oral route and does not need to be classified for acute oral toxicity according to CLP

(REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL) as implementation

of UN-GHS in the EU.

- dermal toxicity: The dermal toxicity Be metal cannot be assessed as no reliable study is available. Given the absence of oral toxicity a classification for acute dermal toxicity is deemed unjustified according to CLP (REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL) as implementation of UN-GHS in the EU.

- inhalation toxicity: Beryllium metal is non-toxic via the inhalation route and does not need to be classified for acute oral toxicity according to CLP (REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL)