Registration Dossier
Registration Dossier
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EC number: 231-555-9 | CAS number: 7632-00-0
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: basic information given
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Epidemiological and Toxicological Aspects of Nitrates and Nitrites in the Environment.
- Author:
- Shuval, H.I. and Gruener, N.:
- Year:
- 1 972
- Bibliographic source:
- AJPH 62, 1045-1052
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
- Objective of study:
- toxicokinetics
Test material
- Reference substance name:
- Sodium nitrite
- EC Number:
- 231-555-9
- EC Name:
- Sodium nitrite
- Cas Number:
- 7632-00-0
- Molecular formula:
- HNO2.Na
- IUPAC Name:
- sodium nitrate
Constituent 1
Test animals
- Species:
- rat
- Details on test animals or test system and environmental conditions:
- pregnant rats
Administration / exposure
- Details on study design:
- The study was conducted on pregnant white albino rats. The transfer of nitrites to the fetus in situ and the production of MetHb was tested.
Results and discussion
Toxicokinetic / pharmacokinetic studies
Toxicokinetic parameters
- Toxicokinetic parameters:
- other: The results of this study demostrated that nitrites were apparently not transfered in appreciable amounts to suckling rats.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
