Registration Dossier
Registration Dossier
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EC number: 231-555-9 | CAS number: 7632-00-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary source
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
- Remarks:
- according to SIDS
Test material
- Reference substance name:
- Sodium nitrite
- EC Number:
- 231-555-9
- EC Name:
- Sodium nitrite
- Cas Number:
- 7632-00-0
- Molecular formula:
- HNO2.Na
- IUPAC Name:
- sodium nitrate
- Details on test material:
- sodium nitrite
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Controls:
- not specified
- Amount / concentration applied:
- Approximately 500 mg of sodium nitrite
- Duration of treatment / exposure:
- 4 hour(s)
- Observation period:
- 3 days
- Number of animals:
- 6
- Details on study design:
- The animals were examined one hour, one, two and three days after removal of the chemical.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1 d
- Score:
- 0
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- Some slight irritation was observed one hour after removal of the substance, but all signs had disappeared by the one day observation and the substance is not considered to be a skin irritant.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
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