Registration Dossier
Registration Dossier
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EC number: 200-909-4 | CAS number: 75-86-5
Toxicity to reproduction
Administrative data
- Endpoint:
- fertility, other
- Remarks:
- based on test type (migrated information)
- Adequacy of study:
- other information
Data source
Reference
- Title:
- No information
- Author:
- Monsanto Co. (1982)|Report ML-82-144|Male fertility study of Sprague-Dawley rats exposed by the|inhalation route to acetone cyanohydrin.|US EPA/OPTS Public files No. 878216404
Materials and methods
- Principles of method if other than guideline:
- Method: other: Similar to OECD.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-hydroxy-2-methylpropionitrile
- EC Number:
- 200-909-4
- EC Name:
- 2-hydroxy-2-methylpropionitrile
- Cas Number:
- 75-86-5
- Molecular formula:
- C4H7NO
- IUPAC Name:
- 2-hydroxy-2-methylpropanenitrile
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4
TS-Freetext:
98.5% Acetone cyanohydrin. Certificate of analysis.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation
- Duration of treatment / exposure:
- Exposure period: 6 hrs/day
Premating exposure period (males): 48 days
Premating exposure period (females): 0 days
Duration of test: 69 days - Frequency of treatment:
- 5 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10, 28.5 & 57.2 ppm
Basis:
- Control animals:
- yes, historical
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- NOAEL
- Effect level:
- 57.2 ppm
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
- Executive summary:
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Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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