Registration Dossier

Guidance on Safe Use

Guidance on Safe Use

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Administrative data

First-aid measures

4.1. Description of first aid measures
General advice
The following recommendations in respect of first aid and therapy should be made available to all First Aid Officers and Doctors, who could be called upon to render first aid, before work with cyanide/hydrocyanic acid is started. If accident occurs or if person feels unwell, call the ambulance immediately (keyword: cyanide). Show label or safety data sheet.First aider needs to protect himself.When handling larger quantities it is recommended to arrange a rescue chain.In case of external emergencies immediately inform doctor on call, fire brigade and police.Move casualty to fresh air outside the danger zone immediately using self-protection with respiratory protection and suitable protective clothing (should be stored inside the truck in case of transportation).Remove contaminated soaked clothing immediately and dispose of safely.
Inhalation
Move subject to fresh air and keep him calm. Call a physician immediately. If breathing is difficult, give oxygen. No artificial respiration, mouth-to-mouth or mouth to nose. Use suitable instruments/apparatus.
Skin contact
Highly toxic. May be fatal if absorbed through the skin. After contact with skin, wash immediately with copious amounts of water sufficient to remove all cyanide. All known cyanide exposures should be observed for systemic cyanide intoxication. Flush wetted skin thoroughly with plenty of water - including burns or other open wounds. Symptoms may include pink or brick red skin color with possible profuse sweating. Keep calm and protect against heat loss. Call a physician immediately. Afterwards local treatment with polyethylene glycol-400 in hospital.
Eye contact
Immediately flush with large amounts of water for at least 15 minutes, lifting upper and lower lids occasionally. Get medical attention immediately. If physician is not immediately available, continue flushing with water. Do not use chemical antidote. Protect unharmed eye. Immediate further treatment in eye clinic/by eye doctor. continue rinsing eye until arrival at ophthalmic hospital. All cyanide eye exposures should be observed and evaluated for possible systemic cyanide intoxication. May be absorbed rapidly through eye exposure to cause systemic toxicity.
Ingestion
Call emergency doctor immediately (alarm report: cyanide / hydro-cyanic acid poisoning ).
Do NOT induce vomiting. Call a physician immediately. All ingestion exposures should be evaluated by a physician. Only if patient is fully conscious and no other symptoms are present, have the mouth rinsed with water and with instructions for the patient not to swallow the water. Treatment and first aid measures should be administered according to symptoms.

4.2. Most important symptoms and effects, both acute and delayed
confusion, unconsciousness

4.3. Indication of any immediate medical attention and special treatment needed
If poisoned casualty still breathes regularly and is not unconscious let him/her rest comfortably with protection against heat
loss.Avoid any strain for the poisoned victim during treatment.In any case make the casualty inhale oxygen, especially if
he/she is unconscious and respiration is still regular.Oxygen supply must be absolutely maintained !In case of
unconsciousness, disordered respiration or respiratory arrest, immediate intensive artificial respiration o n l y with
respiration bag or special respiration by doctor on call must be supplied.Specific therapy/antidote: 4-DMAP, sodium
thiosulfate, if permitted, otherwise any other preparations against hydrocyanic acid poisoning that are permitted in the
respective countries.

Fire-fighting measures

5.1. Extinguishing media
Suitable extinguishing media water spray, foam, carbon dioxide

Extinguishing media which must not be used for safety reasons
High volume water jet alkaline extinguishing media (e.g. on the basis of sodium or
potassium carbonate - formation of hydrogen cyanide !)

5.2. Special hazards arising from the substance or mixture
Products or compounds possibly released in case of fire: nitrous gases (nitrogen oxides) hydrogen cyanide vapours

5.3. Advice for firefighters
Wear self-contained breathing apparatus.
Use extinguishing measures that are appropriate to local circumstances and the surrounding environment. Keep out unprotected persons. Containers exposed to heat (fire) may build up pressure. Cool by splashing with water. Closed container may rupture if strongly heated. Prevent fire extinguishing water from contaminating surface water or the ground water system. Ensure there are sufficient retaining facilities for water used to extinguish fire. Water used to extinguish fire should not enter drainage systems, soil or stretches of water. Fire residues and contaminated fire extinguishing water must be disposed of in accordance with local regulations.

Accidental release measures

6.1. Personal precautions, protective equipment and emergency procedures
Keep out unprotected persons. Assure sufficient ventilation. Use personal protective clothing. Do not breathe vapours or spray mist. As a rule, work only with respiratory protective equipment. Keep away sources of ignition. Evacuate the vicinity. Evacuate personnel to safe areas. Keep people away from and upwind of spill/leak.

6.2. Environmental precautions
Do not allow entrance in sewage water, soil, stretches of water, drainage systems, surface water. If the product contaminates rivers and lakes or drains inform respective authorities. Cyanide-containing sewage water and solutions must be decontaminated before entering a public canal network or stretch of water.

6.3. Methods and material for containment and cleaning up
Larger quantities: Remove mechanically (by pumping). Use explosion-proof equipment! Smaller quantities and/or residues: Contain with absorbent material (e.g. sand, diatomaceous earth, acid absorbent, universal absorbent or sawdust). Dispose of in accordance with regulations. Cyanide-containing sewage water and solutions must be decontaminated before entering a public canal network or stretch of water.
See chapter 8 for information on personal protective equipment.

6.4. Reference to other sections
For personal protection see section 8.

Handling and storage

7.1. Precautions for safe handling
Safe handling advice
Keep container tightly closed. Avoid contact with skin, eyes and clothing. Provide good room ventilation even at ground level (vapours are heavier than air). Contamination with bases must be absolutely avoided. Take precautionary measures against static discharges. Acetone cyanohydrin must always be kept slightly acidic. Access only for technical experts. Follow all SDS/label precautions even after container is emptied because it may retain product residues. Keep locked up. The product should only be handled by trained personnel. Use permissible in closed systems only. Handle and transfer product in closed systems only (gas displacement device). Ensure that apparatus and pipelines are free from leaks. Do not ventilate into the open. Suitable loading and unloading device required.

Advice on protection against fire and explosion
Keep away from sources of ignition --- No smoking. Take precautionary measures against static discharges. In the event of fire, cool the endangered containers with water. Vapours are heavier than air and may spread along floors. When heated above the flash point and/or during spraying (atomizing), ignitible mixtures may form in air. Use only explosion-proof equipment.

7.2. Conditions for safe storage, including any incompatibilities
Requirements for storage areas and containers
Keep only in the original container in a cool, well-ventilated place. Fill the container by approximately 95% only. Keep away from open flames, hot surfaces and sources of ignition. Avoid sun rays, heat, heat effect. Keep locked up. Keep container tightly closed. Monitoring of ambient air necessary.

Advice on common storage
Do not store together with alkalies. Do not store together with oxidizing substances. Do not store together with highly flammable solid substances. Do not store together with self-igniting materials or substances.

German storage class
Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials.

7.3. Specific end use(s)
no

Transport information

Land transport (ADR/RID)

UN number:
UN 1541
Proper shipping name and description:
UN 1541 ACETONE CYANOHYDRIN, STABILIZED, 6.1, I (C/E), Environmental Hazardous
Hazard no. 669
Chemical name:
ACETONE CYANOHYDRIN, STABILIZED
Language:
English
Class:
6.1
Packaging group:
I
Labels:
(C/E)
SpecialProvisionsopen allclose all

Inland waterway transport (ADN(R))

UN number:
UN 1541
Proper shipping name and description:
UN 1541 ACETONE CYANOHYDRIN, STABILIZED, 6.1, I, (C/E)
Hazard no. 669
Chemical name:
ACETONE CYANOHYDRIN, STABILIZED
Language:
English
Class:
6.1
Packaging group:
I
Labels:
(C/E)
Remarksopen allclose all

Marine transport (IMDG)

UN number:
1541
Subsidiary risk: MP
Proper shipping name and description:
ACETONE CYANOHYDRIN, STABILIZED
Class:
6.1
Packaging group:
I
EmS code:
F-A, S-A
Marine pollutant
Remarksopen allclose all

Air transport ICAO/IATA

UN number:
1541
Proper shipping name and description:
ACETONE CYANOHYDRIN, STABILIZED
Class:
6.1
Packaging group:
I
Remarks
Transport prohibited !
SpecialProvisionsopen allclose all

Exposure controls / personal protection

8.1. Control parameters
Components or products of decomposition according to point 10, with limit values related to the place of work which require monitoring

hydrogen cyanide 74-90-8
Skin designation: 12 2011
Can be absorbed through the skin.
Short Term Exposure Limit (STEL): 12 2011
11 mg/m3
10 ppm

acetone 67-64-1
Time Weighted Average (TWA): 12 2011
1,210 mg/m3
500 ppm
Short Term Exposure Limit (STEL): 12 2011
3,620 mg/m3
1,500 ppm
Time Weighted Average (TWA): 12 2009
1,210 mg/m3
500 ppm
Indicative

8.2. Exposure controls
For monitoring procedures refer for instance to "Empfohlene Analysenverfahren für Arbeitsplatzmessungen", Schriftenreihe der Bundesanstalt für Arbeitsschutz and "NIOSH Manual of Analytical Methods", National Institute for Occupational Safety and Health Refill and handle product only in closed system. Leak detection recommended Do not add wastewater to a biological wastewater treatment plant Minimization of emissions by means of suitable technical measures such as flanges and valves with low leakage rates, recirculation of vapours. All precautionary measures indicated have to be observed.
The substance must be handled under strictly controlled conditions in accordance with Article 17/18 of the REACH regulation.

Protective measures
Do not breathe vapours. Absolutely avoid contact with the eyes and/or skin. No eating, drinking, smoking, or snuffing tobacco at work. All precautionary measures indicated have to be observed. Risk assessment and risk monitoring of all work places required. Health, Safety and Emergency Management System recommended. Regular safety training is a must. Written approval necessary in case of non-routine jobs, e.g. maintenance activities.
Ensure that eye flushing systems and safety showers are located close to the working place.

Hygiene measures
Store work clothing separately. Take off all contaminated clothing immediately. Follow the usual good standards of occupational hygiene. Clean skin thoroughly after work; apply skin cream. Take off clothing and shoes contaminated with product. Clean before reuse.

Respiratory protection
Do not inhale vapour, aerosols, mist., If open handling is unavoidable:, short term: filter appliance, combination filter AB/P3, wear a self contained respiratory apparatus.

Hand protection
butyl rubber gloves (0.7 mm), Break through time 60 min (EN 374)
In practice, due to variable exposure conditions, this information can only be an aid to orientation for the selection of a suitable chemical protection glove. In particular, this information does not substitute suitability tests by the end user.

Splash protection
neoprene gloves

General information
Gloves should be replaced regularly, especially after extended contact with the product. For each work-place a suitable glove type has to be selected.

Eye protection
tightly fitting goggles

Skin and body protection
Choose body protection according to the amount and concentration of the dangerous substance at the work place. Accidental release measures chemical protective suit if necessary: face protection, rubber boots, apron made of rubber Do not inhale vapors / aerosol. Remove contaminated or saturated clothing. Avoid contact with skin, eyes and clothing.

Stability and reactivity

10.1. Reactivity
see section 10.2.

10.2. Chemical stability
>120 °C Decomposition

10.3. Possibility of hazardous reactions
Violent reactions with concentrated acids, alkalis and oxidizing agents.

10.4. Conditions to avoid
Decomposition at elevated temperatures.

10.5. Incompatible materials
Violent reactions with concentrated acids, alkalis and oxidizing agents.

10.6. Hazardous decomposition products
Hazardous decomposition products: hydrogen cyanide, acetone

Disposal considerations

13.1. Waste treatment methods

Product
Waste is hazardous. It must be disposed of in accordance with the regulations after consultation of the competent local authorities and the disposal company in a suitable and licensed facility. Strictly controlled conditions during disposal or treatment to air, wastewater and waste. Bring wastewater containing AOX for professional disposal. Disposal according to local authority regulations. Do not add wastewater to a biological wastewater treatment plant.

Uncleaned packaging
Contaminated packaging should ideally be emptied; it can then be recycled after having been decontaminated. Packaging that cannot be cleaned should be disposed of professionally. Uncontaminated packaging may be taken for recycling.

Code of waste EWC
07 02 08
waste from the manufacture, formulation, supply and use (MFSU) of plastics, synthetic rubber and man-made fibres - other still bottoms and reaction residues
Always check the given waste codes according to the actual conditions of manufacturing, formulation or use in your facilities.