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EC number: 203-794-9 | CAS number: 110-71-4
Skin sensitising potential of Diethylene glycol methyl ethyl ether was tested in one Local Lymph Node Assay (LLNA) according to OECD test guideline 429. In this assay S.I. of 0.73, 1.03 and 0.69 were determined with the test item at concentrations of 25%, 50% and 100% in acetone:olive oil (4 +1).
There are no respiratory sensitization properties of the substance known in literature. Beyond this there is no hint of any sensitization property of the compound from the LLNA study. Therefore, it is concluded that the subsance is not a respiratory sensitizer.
Ethylene glycol dimethyl ether and Diethylene glycol methyl ethyl ether, which is tested for its sensitising potential, belong to the glycol ether family. These substances have been demonstrated to be very similar in structure, physical/chemical properties and the toxicological profile. Due to the fact that Ethylene glycol dimethyl ether and Diethylene glycol methyl ethyl ether have nearly the same chemical structure (especially with reference to the functional groups):
1. Ethylene glycol dimethyl ether: H3C-O-CH2-CH2-O-CH3
2. Diethylene glycol methyl ethyl ether: H3C-O-CH2-CH2 -O -CH2-CH2-O-CH2-CH3
the same mode of interaction with living cells and tissue is expected. Therefore, a read across from Ethylene glycol dimethyl ether to data obtained with Diethylene glycol methyl ethyl ether is scientifically justified.
A classification concerning respiratory sensitizing properties is not warranted as the classification criteria according to EU regulation 1272/2008 and 67/548 are not met.
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