Registration Dossier

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

Cationic surfactants like Dimethyl alkylamines (DMAs) sorb strongly to negatively charged surfaces like glass or biota. In order to avoid sorption to the glass of the test vessel and on the test organism well characterized river was used as aquatic medium to allow relable test results. In the following the acute and chronic ecotoxictiy values in river water are given for all DMA category members to allow a direct comparison of the test results.

Short-term aquatic toxicity tests with natural river water for the DMA Category

C10 DMA C12 DMA C12-14 DMA C14 DMA C12-16 DMA C16 DMA C12-18 DMA C16-18 DMA C16-18u DMA C18 DMA
Acute Fish Toxicity
OECD 203
LC50 (96h) [mg/L]
 1.13   0.62      0.256    0.82    
Acute Daphnia Toxicity
OECD 202
EC50 (48h) [ µg/L]
926   55.8      66.5   188    
Algae Growth inhibition
OECD 201
ErC50 (72h) [ µg/L]
26.8    56     9.9   20.1   14.1

Long-term aquatic toxicity tests with natural river water for the DMA Category

C10 DMA C12 DMA C12-14 DMA C14 DMA C12-16 DMA C16 DMA C12-18 DMA C16-18 DMA C16-18u DMA C18 DMA
Long-term toxicity to fish*                  
Long-term toxicity to Daphnia
OECD 211
NOEC repro (21d) [ µg/L]
  36       100    
Algae Growth inhibition
OECD 201
ErC10 (72h) [ µg/L]
4.3    20     2.6**     5.9

* was not tested as fish is not the most sensitive species & for animal welfare reasons

** see discussion in IUCLID Chapter 6.0 PNEC & Conclusion on C&L and 6.1.5 Toxicity to algae

In addition results on the toxicity to microorganisms are given:

Tests on Sludge respriation inhibition for the DMA Category

C10 DMA C12 DMA C12-14 DMA C14 DMA C12-16 DMA C16 DMA C12-18 DMA C16-18 DMA C16-18u DMA C18 DMA
Activated sludge respiration inhibition,
OECD 209
EC50 (3h) [ mg/L]
32.6 27.3 80   30.8 40 13 38   1000