Registration Dossier

Administrative data

Endpoint:
bioaccumulation in aquatic species: fish
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance has a low potential for bioaccumulation based on log Kow <=3 and a low potential to cross biological membranes
Justification for type of information:
For the determination of the BCF fish of cationic surfactants classical test methods like OECD 305 are not suitable as the test substance sorbs to negatively charged surfaces like glass and fish leading to incorrect results. Therefore modeling is currently the most reliable approach to estimate the bioaccumulation potential. The Arnot & Gobas Model (2003) for the estimation of the BCF fish takes into adsorption, distribution, metabolism and excretion (ADME) of a substance in fish. This model is included in the US EPA Estimation program BCF BAF Version 3.01. The highest estimated BCF fish for DMAs is 223 which is well below the B criteria for the PBT / vPvB Assessment. This value may be used for the assessment of secondary poisioning. This modelling approach is explained in detail in the IUCLID 'Endpoint summary Bioaccumulation'.

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion