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EC number: 214-263-6 | CAS number: 1118-46-3
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- calculation method. documentation see attached study report
- GLP compliance:
- no
- Other quality assurance:
- ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
- Type of method:
- estimation method (solubility ratio)
- Partition coefficient type:
- octanol-water
- Analytical method:
- other: not rrquired, calculation
- Key result
- Type:
- Pow
- Partition coefficient:
- 0
- Temp.:
- 20 °C
- pH:
- > 3 - < 9
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1
- Temp.:
- 20 °C
- pH:
- 3 - < 9
- Conclusions:
- the partition coefficient of momobutyltin trichloride was calculated to be log Pow = 1, based on solobility in water and n-octanol
Reference
Description of key information
It was not possible to perform the test due to the low water solubility of the material and technical difficulties arising in the analysis of the material. Furthermore it is not possible to calculate a value as there are no validated QSAR methods for organometallics. The key value used was the Mean Kow determined from the bioaccumulation study, Tsuda et al (1988)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.145
Additional information
Until very recently, the substance was considered to exhibit properties such that a waiver has been submitted to address this end point based on data to suggest the substance rapidly hydrolysed. This is no longer believed to be the case and new information now indicates the substance may in fact behave differently than originally thought. A new partition coefficient study is therefore to be attempted to try and obtain a definitive result. The study is expected to be finished second quarter 2019 and the registration is proposed to be updated to take account of this information in late secoond quarter/ third quarter 2019.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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