Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 214-263-6 | CAS number: 1118-46-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Environmental stability:
The substance is not readily biodegradable. The key study for biodegradability (Hansveit, 2003), reported 0% degradation of the registered substance after 35 days.
The substance has recently been determined not to exhibit rapid hydrolysis. The key study Kleinmaier and Heitmann (2018), indicated that irreversible hydrolysis occurs on a timeframe of one to six days upon dissolution of MBTCl in neutral water, mildly or strongly acidic aqueous solutions of hydrochloric acid in water. The substance is therefore considered as persistent.
Bioaccumulation:
The bioaccumulation of MBTC was studied in carp by Tsuda in 1988. After an uptake period of 14 days BCFs of 2, 126, 50 and 126 were obtained in muscle, liver, kidney and gall bladder respectively. These BCFs are significantly below 2000 and indicate that the risk of bioaccumulation and subsequent biomagnification in the food chain is low.
The worst case BCF value does not meet the criteria for classification as a bioaccumulative or very bioaccumulative substance as set out by Annex XII of EC Regulation 1907/2008.
Adsorption/desorption:
The study by Berg et al (2001) investigated the reversibility of sorption of n-butyltin trichloride in different sediment samples from different sites. Sorption-desorption batch experiments were conducted using contaminated freshwater harbour sediments and two certified organotin containing marine sediments. To distinguish between the organotins originally present in these sediments and the freshly sorbed organotins, sorption experiments were carried out using perdeuterated standard compounds. Findings from the study indicate that sorption of organotin compounds to sediments is a fast and reversible process involving primarily particulate organic matter constituents as sorbents. The study found that, in general, organotin compounds will readily desorb and, therefore, be more readily bioavailable. The log Kd values that were determined for n-butyltin trichloride ranged from 3.15 to 4.92 L/kg. Experimental results normalised for carbon content in the sediment indicated that log Doc values were in the range of 5.12 to 4.65 which are in the same range as the in situ measured values of 4.61 to 4.92 L/Kg.
The experimentally derived Log Doc value of 4.65 was selected for chemical safety assessment as it is considered the most reliable (due to being obtained in controlled experimental conditions) and results in a worst-case scenario with regards to potential exposure to the substance in the modelling conducted in the CSR.
Until very recently, the substance was considered to exhibit properties, such as rapid hydrolysis, such that waivers were submitted to cover this endpoint as certain studies were considered technically not feasible. As part of the ongoing CoRAP evaluation additional investigations have been, and are currently being, conducted and studies are still ongoing. Current evidence suggests that the substance may in fact behave differently than originally thought and as such the results presented in Berg et al. (2001) are considered to accurately reflect the behaviour of the substance with regards to its adsorption/desorption.
Additional information
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