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Diss Factsheets
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EC number: 406-860-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Remarks:
- modified AFNOR-TEST
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 June 1990 - 24 July 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 A (old version) (Ready Biodegradability: Modified AFNOR Test)
- Deviations:
- yes
- Remarks:
- -Sterilization instead of steril filtration. - Determination of bacteria concentration: by plating. - Inoculum: effluent of a domestic sewage. treatment plant(see "any other information on materials and methods")
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-A (Determination of the "Ready" Biodegradability - Dissolved Organic Carbon (DOC) Die-Away Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Test substance: FAT-40400/A
Stability: guaranteed by the sponsor
Solubility: ca. 100 g/l
Storage: room temperature
Appearance: solid - Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, domestic (adaptation not specified)
- Details on inoculum:
- - Strain/Inoculation: Mixture of polyvalent bacteria collected on 26.06.90 (effluent of a domestic sewage treatment plant (ARA-Rhein)).
- Bacteria concentration: 1.0E+07/mL. - Duration of test (contact time):
- 28 d
- Initial conc.:
- 40 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- - Water/nutrient: according to guideline
- Temperature: 25 ± 1 °C
- Lighting: Indirect lighting
- Estimation technique: TOC/DOC SHIMADZU TOC-500 - Reference substance:
- other: glucose
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- ca. 0
- Remarks on result:
- other: sampling time not reported
- Details on results:
- Biodegradation corrected by the blank control and measured as DOC (mg/L) for the test substance is: 0 % (28th day)
- Results with reference substance:
- Biodegradation corrected by the blank control and measured as DOC (mg/L) for the reference substance (glucose) is: 100 % (28th day)
- Validity criteria fulfilled:
- yes
- Remarks:
- Difference of DOC values of replicates at the end of the test (28th day) is not more than 20 % and degradation of reference substance has reached the pass value within 14 days. Also the substance is not inhibitory (301 Guideline criteria, 1992).
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- FAT 40400/A is not readily biodegradable (0% DOC) under the test conditions.
- Executive summary:
In a ready biodegradability test performed according to OECD Guideline 301A (modified AFNOR test), biodegradation of the test substance by microorganisms was determined. In this study, a mixture of polyvalent bacteria (1.0E+07/mL) from an effluent of a domestic sewage treatment plant (ARA-Rhein) was exposed to 40 mg/L DOC of test substance for 28 days. After 28 days no biodegradation was observed. The results from inhibitory control showed that no inhibition of the activity of the bacteria can be found.
Biodegradation corrected by the blank control and measured as DOC (mg/L) for the reference substance (glucose) is: 100 % (28th day).
Reference
Description of key information
In a key study, the ready biodegradability of the test substance was determined in a GLP-compliant study according to OECD Guideline 301A (CG, 1990). The initial test substance concentration was 40 mg/L based on DOC. Biodegradation of the test substance after 28 days was found to be 0 %. No inhibition on the activity of the bacteria was observed in a inhibition control. The substance is to be considered not readily biodegradable.
Biological oxygen demand over 5 days (BOD5) was determined in a study performed according to the EEC, Annex V, part C.8 guideline (D&C, 1988). In this study, a mixed culture of bacteria (effluent of a Husman laboratory apparatus) was exposed to 1, 5, 10, 20, 50, 100, 200 and 500 mg of test substance/L. The BOD5 of the test substance, corrected by the blank control, was 0 mg/g oxygen. The chemical oxygen demand (COD) of the test substance was determined in a study performed according to the EEC, Annex V, part C.9 guideline (D&C) under GLP. In this study, 5 mg of the test substance were exposed to 148 °C for 2 hours. The COD of the test substance was estimated 773 mg O2/g test item. The BOD5/COD ratio supports the conclusion that the test substance is not readily biodegradable. Reactive Yellow 181 was reported to be not readily biodegradable in a 2019 study conducted by MITI, Japan. The details about the study are not available.
Key value for chemical safety assessment
- Biodegradation in water:
- not biodegradable
- Type of water:
- freshwater
Additional information
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